ArticleThe Journal of cell biology1989
An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme.Biomedicines · 2021Review
- Hepatic Insulin Clearance: Mechanism and Physiology.Physiology (Bethesda, Md.) · 2019Review
- Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.PloS one · 2012Article
- Toxoplasma gondii toxolysin 4 is an extensively processed putative metalloproteinase secreted from micronemes.Molecular and biochemical parasitology · 2011Article
- Overexpression of Insulin Degrading Enzyme could Greatly Contribute to Insulin Down-regulation Induced by Short-Term Swimming Exercise.Laboratory animal research · 2011Article
- Genetic diversity of the Cryptococcus species complex suggests that Cryptococcus gattii deserves to have varieties.PloS one · 2009Article
- Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.Biochemistry · 2008Article
- Insulysin: an allosteric enzyme as a target for Alzheimer's disease.Journal of molecular neuroscience : MN · 2005Article
- Comparison of the antisecretory and antiulcer activity of epidermal growth factor, urogastrone and transforming growth factor alpha and its derivative in rodents in vivo.Molecular and cellular biochemistry · 2002Article
- Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines.The Biochemical journal · 2000Article
- Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.The Biochemical journal · 2000Article
- Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.Neurochemical research · 2000Article
- Preparation and characterization of novel substrates of insulin proteinase (EC 3.4.99.45).The Biochemical journal · 1994Article
- Effect of transforming growth factor-alpha on gastric acid secretion in rats and monkeys.Digestive diseases and sciences · 1994Article
- Growth factors in invertebrate in vitro culture.In vitro cellular & developmental biology : journal of the Tissue Culture Association · 1991Review
- Native avian c-erbB gene expresses a secreted protein product corresponding to the ligand-binding domain of the receptor.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A single enzyme found in both Drosophila and mammalian cells is able to selectively bind and degrade transforming growth factor (TGF)-alpha and insulin, but not EGF, at physiological concentrations. These growth factors are also able to inhibit binding and degradation of one another by the enzyme. Although there are significant immunological differences between the mammalian and Drosophila enzymes, the substrate specificity has been highly conserved. These results demonstrate the existence of a selective TGF-alpha-degrading enzyme in both Drosophila and mammalian cells. The evolutionary conservation of the ability to degrade both insulin and TGF-alpha suggests that this property is important for the physiological role of the enzyme and its potential for regulating growth factor levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.