Evidence map›Paper›PMID 26709389›Full record

ArticleBiochemistry and biophysics reports2016

Sulfite Oxidase Activity of Cytochrome c: Role of Hydrogen Peroxide.

Murugesan Velayutham, Craig F Hemann, Arturo J Cardounel, Jay L Zweier

Open access · goldAbstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Internalization of theInternational journal of molecular sciences · 2020
    Article
  8. Review
  9. Review
  10. Review
  11. Sulfur dioxide induces apoptosis via reactive oxygen species generation in rat cardiomyocytes.Environmental science and pollution research international · 2019
    Article
  12. Review
  13. Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Murugesan VelayuthamCenter for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, and Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio 43210 ; Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15219.
Craig F HemannCenter for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, and Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio 43210.
Arturo J CardounelDepartment of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15219.
Jay L ZweierCenter for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, and Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio 43210.
The Ohio State University · USUniversity of Pittsburgh Medical Center · US

Funding

Stat3 in Post-Ischemic Myocardial InflammationP01HL065608 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BECKER, LEWIS C · 2000 to 2011
$22.0M
OXYGEN RADICALS AND NITRIC OXIDE IN POSTISCHEMIC INJURYR01HL063744 · NHLBI · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2000 to 2009
$5.2M
MEASURE OF FREE RADICAL GENERATION IN HEARTR01HL038324 · NHLBI · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 1992 to 2010
$3.5M
Methylarginines and Vascular InjuryR01HL081734 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARDOUNEL, ARTURO J · 2006 to 2014
$2.8M
Integration of High Field MRI and EPRI For Functional ImagingR01EB016096 · NIBIB · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2013 to 2016
$2.3M
NHLBI NIH HHS P01 HL065608NHLBI NIH HHS R01 HL038324NHLBI NIH HHS R01 HL063744NHLBI NIH HHS R01 HL081734NIBIB NIH HHS R01 EB016096
6 · The paper itself

Abstract

In humans, sulfite is generated endogenously by the metabolism of sulfur containing amino acids such as methionine and cysteine. Sulfite is also formed from exposure to sulfur dioxide, one of the major environmental pollutants. Sulfite is used as an antioxidant and preservative in dried fruits, vegetables, and beverages such as wine. Sulfite is also used as a stabilizer in many drugs. Sulfite toxicity has been associated with allergic reactions characterized by sulfite sensitivity, asthma, and anaphylactic shock. Sulfite is also toxic to neurons and cardiovascular cells. Recent studies suggest that the cytotoxicity of sulfite is mediated by free radicals; however, molecular mechanisms involved in sulfite toxicity are not fully understood. Cytochrome c (cyt c) is known to participate in mitochondrial respiration and has antioxidant and peroxidase activities. Studies were performed to understand the related mechanism of oxidation of sulfite and radical generation by ferric cytochrome c (Fe

Indexed as

cytochrome cElectron paramagnetic resonance (EPR)mitochondriaperoxidase activityspin trappingsulfite radical

Identifiers

PMID26709389
PMCPMC4689149
OpenAlexW2192160570

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.