Evidence map›Paper›PMID 26709382›Full record

ArticleAJOB empirical bioethics

An exploratory study of therapeutic misconception among incarcerated clinical trial participants.

Paul P Christopher, Michael D Stein, Sandra A Springer, Josiah D Rich, Jennifer E Johnson, Charles W Lidz

Abstract read
In one paragraph

Article in AJOB empirical bioethics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Therapeutic Misconception as a Problem of Nonmaleficence by Way of False Hope.Health care analysis : HCA : journal of health philosophy and policy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paul P ChristopherAlpert Medical School Brown University.
Michael D SteinAlpert Medical School Brown University.
Sandra A SpringerYale University School of Medicine.
Josiah D RichAlpert Medical School Brown University.
Jennifer E JohnsonAlpert Medical School Brown University.
Charles W LidzUniversity of Massachusetts Medical School.

Funding

Midcareer Investigator Award in Patient Oriented ResearchK24DA022112 · NIDA · MIRIAM HOSPITAL · PI RICH, JOSIAH D · 2008 to 2017
$1.7M
Measuring Prisoners' Voluntary Consent to Clinical Research for Opioid DependenceK23DA034030 · NIDA · BUTLER HOSPITAL (PROVIDENCE, RI) · PI CHRISTOPHER, PAUL PASQUALE · 2013 to 2017
$883k
NIDA NIH HHS K23 DA034030NIDA NIH HHS K24 DA022112
6 · The paper itself

Abstract

backgroundTherapeutic misconception, the misunderstanding of differences between research and clinical care, is widely prevalent among non-incarcerated trial participants. Yet little attention has been paid to its presence among individuals who participate in research while incarcerated.

methodsThis study examined the extent to which seventy-two incarcerated individuals may experience therapeutic misconception about their participation in one of six clinical trials, and its correlation with participant characteristics and potential influences on research participation.

resultsOn average, participants endorsed 70% of items suggestive of therapeutic misconception. The tendency toward therapeutic misconception was significantly higher among: African Americans and Latinos compared to Whites; older and less educated participants; enrollment in a substance abuse-related trial; and correlated with a belief that the trial was the only way to obtain needed treatment.

conclusionsTherapeutic misconception may be particularly high among select incarcerated individuals and is associated with a perceived lack of treatment options. Further examination of therapeutic misconception among incarcerated research participants is needed.

Indexed as

incarcerationinformed consentprisonerstherapeutic misconceptionvulnerable populations

Identifiers

PMID26709382
PMCPMC4687735

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.