ArticleAJOB empirical bioethics
Cancer clinical trial participants' assessment of risk and benefit.
Article in AJOB empirical bioethics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Descriptions of risks and benefits of HIV vaccine trials in low-and middle-income countries (LMICs): an integrative review.BMC medical ethics · 2025Pooled it
- Informed consent and ethical reporting of research in clinical trials involving participants with psychotic disorders.Contemporary clinical trials · 2019Pooled it
- Trial
- Motivations, acceptability and ethical considerations for interventional HIV cure research at the end of life: perspectives from long-term survivors of HIV in the United States.BMC medical ethics · 2025Article
- Proportion of patients in phase 2 oncology trials receiving treatments that are ultimately approved.Journal of the National Cancer Institute · 2025Article
- Age Differences in Clinical Trial Understanding in Non-Hodgkin Lymphoma Patients.Clinical lymphoma, myeloma & leukemia · 2022Article
- Experiences of Patients After Withdrawal From Cancer Clinical Trials.JAMA network open · 2021Article
- Motivations and Decision-Making of Adult Sickle Cell Patients in High-Risk Clinical Research.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020Article
- Tissue vs Liquid Biopsies for Cancer Detection: Ethical Issues.Journal of bioethical inquiry · 2019Article
- Assessment of adherence and relative dose intensity with oral chemotherapy in oncology clinical trials at an academic medical center.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2018Article
- Development and Preliminary Testing of the Perceived Benefit and Burden Scales for Cancer Clinical Trial Participation.Journal of empirical research on human research ethics : JERHRE · 2018Article
- Article
- Informed Consent among Clinical Trial Participants with Different Cancer Diagnoses.AJOB empirical bioethicsArticle
- Which Benefits Are Mentioned Most Often in Drug Development Publications?Current therapeutic research, clinical and experimentalArticle
- Cancer Clinical Trial Patient-Participants' Perceptions about Provider Communication and Dropout Intentions.AJOB empirical bioethicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThe purpose of this article is to examine the extent to which cancer clinical trial participants assess the benefits and risks of research participation before enrollment.
methodsOne hundred and ten oncology research participants enrolled in cancer clinical research in a large Northeastern cancer center responded to a self-administered questionnaire on perceptions about cancer clinical trials.
resultsOf the participants, 51.6% reported they did not directly assess the benefits or risks. Educational level, age, employment, treatment options, insurance, and spiritual-religious beliefs were significantly associated with whether participants assessed risk and benefits. Those who felt well informed were more likely to have assessed the benefits and risks at enrollment than those who did not feel well informed (odds ratio [OR] = 3.92,
conclusionOur findings have important implications for understanding the role of assessing risks and benefits in the research participation decisions of patients with cancer and call for further understanding of why participants are not assessing information believed to be essential for autonomous informed decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.