Evidence map›Paper›PMID 26709263›Full record

ArticleAnnals of laboratory medicine2016

Survey of Clinical Laboratory Practices for 2015 Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea.

Mi-Kyung Lee, Sinyoung Kim, Mi-Na Kim, Oh Joo Kweon, Yong Kwan Lim, Chang-Seok Ki, Jae-Seok Kim, Moon-Woo Seong, Heungsup Sung, Dongeun Yong and 4 more

Abstract read
In one paragraph

Article in Annals of laboratory medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mi-Kyung LeeDepartment of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Sinyoung KimDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
Mi-Na KimDepartment of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Oh Joo KweonDepartment of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Yong Kwan LimDepartment of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Chang-Seok KiDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jae-Seok KimDepartment of Laboratory Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Moon-Woo SeongDepartment of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
Heungsup SungDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Dongeun YongDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
Hyukmin LeeDepartment of Laboratory Medicine, Catholic Kwandong University College of Medicine, Incheon, Korea.
Jong-Rak ChoiDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
Jeong-Ho KimDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. jeongho@yuhs.ac.
MERS-CoV Laboratory Response Task Force of The Korean Society for Laboratory Medicine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is crucial to understand the current status of clinical laboratory practices for the largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infections in the Republic of Korea to be well prepared for future emerging infectious diseases.

methodsWe conducted a survey of 49 clinical laboratories in medical institutions and referral medical laboratories. A short questionnaire to survey clinical laboratory practices relating to MERS-CoV diagnostic testing was sent by email to the directors and clinical pathologists in charge of the clinical laboratories performing MERS-CoV testing. The survey focused on testing volume, reporting of results, resources, and laboratory safety.

resultsA total of 40 clinical laboratories responded to the survey. A total of 27,009 MERS-CoV real-time reverse transcription PCR (rRT-PCR) tests were performed. Most of the specimens were sputum (73.5%). The median turnaround time (TAT) was 5.29 hr (first and third quartile, 4.11 and 7.48 hr) in 26 medical institutions. The median TAT of more than a half of the laboratories (57.7%) was less than 6 hr. Many laboratories were able to perform tests throughout the whole week. Laboratory biosafety preparedness included class II biosafety cabinets (100%); separated pre-PCR, PCR, and post-PCR rooms (88.6%); negative pressure pretreatment rooms (48.6%); and negative pressure sputum collection rooms (20.0%).

conclusionsClinical laboratories were able to quickly expand their diagnostic capacity in response to the 2015 MERS-CoV outbreak. Our results show that clinical laboratories play an important role in the maintenance and enhancement of laboratory response in preparation for future emerging infections.

Indexed as

Clinical Laboratory ServicesClinical Laboratory TechniquesCoronavirus InfectionsDisease OutbreaksHumansMiddle East Respiratory Syndrome CoronavirusReal-Time Polymerase Chain ReactionRepublic of KoreaRNA, ViralSputumSurveys and QuestionnairesRNA, ViralClinical laboratoryKoreaMiddle East respiratory syndrome coronavirus (MERS-CoV)OutbreakPreparednessSurvey

Identifiers

PMID26709263
PMCPMC4713849

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.