ArticleThe Journal of biological chemistry2016
Identification and Characterization of the Iridoid Synthase Involved in Oleuropein Biosynthesis in Olive (Olea europaea) Fruits.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Article
- Antimicrobial and antibiofilm actions of iridoids: a comprehensive mechanistic review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Identification and Optimization of Kratom Strictosidine Pathway Enabled by Yeast Multiplex Engineering.bioRxiv : the preprint server for biology · 2026Article
- Analysis of the Rehmannia chingii geneome identifies RcCYP72H7 as an epoxidase in iridoid glycoside biosynthesis.Nature communications · 2025Article
- A Comprehensive Review of Moroccan Medicinal Plants for Diabetes Management.Diseases (Basel, Switzerland) · 2024Review
- Comprehensive Review ofBiomolecules · 2024Review
- Transcriptome and metabolome analysis revealed the dynamic change of bioactive compounds of Fructus Ligustri Lucidi.BMC plant biology · 2024Article
- Canopy Architectural Characteristics of Ten New Olive (Plants (Basel, Switzerland) · 2024Article
- Transcriptome Analysis Provides Insights into Catalpol Biosynthesis in the Medicinal PlantGenes · 2024Article
- Bacillus G7 improves adaptation to salt stress in Olea europaea L. plantlets, enhancing water use efficiency and preventing oxidative stress.Scientific reports · 2023Article
- Transcriptome-based identification and functional characterization of iridoid synthase involved in monotropein biosynthesis in blueberry.Plant direct · 2023Article
- Functional iridoid synthases from iridoid producing and non-producingFrontiers in plant science · 2023Article
- Article
- Domestic cat damage to plant leaves containing iridoids enhances chemical repellency to pests.iScience · 2022Article
- Identification and functional characterization of three iridoid synthases in Gardenia jasminoides.Planta · 2022Article
- Biophenolic Profile Modulations in Olive Tissues as Affected by Manganese Nutrition.Plants (Basel, Switzerland) · 2021Article
- Identification and Functional Characterization of Genes Encoding Phenylacetaldehyde Reductases That Catalyze the Last Step in the Biosynthesis of Hydroxytyrosol in Olive.Plants (Basel, Switzerland) · 2021Article
- Bioactive Potential of Minor Italian Olive Genotypes from Apulia, Sardinia and Abruzzo.Foods (Basel, Switzerland) · 2021Article
- De novo assembly of a new Olea europaea genome accession using nanopore sequencing.Horticulture research · 2021Article
- Oleocanthal Quantification UsingMolecules (Basel, Switzerland) · 2021Article
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7 authors.
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Abstract
The secoiridoids are the main class of specialized metabolites present in olive (Olea europaea L.) fruit. In particular, the secoiridoid oleuropein strongly influences olive oil quality because of its bitterness, which is a desirable trait. In addition, oleuropein possesses a wide range of pharmacological properties, including antioxidant, anti-inflammatory, and anti-cancer activities. In accordance, obtaining high oleuropein varieties is a main goal of molecular breeding programs. Here we use a transcriptomic approach to identify candidate genes belonging to the secoiridoid pathway in olive. From these candidates, we have functionally characterized the olive homologue of iridoid synthase (OeISY), an unusual terpene cyclase that couples an NAD (P)H-dependent 1,4-reduction step with a subsequent cyclization, and we provide evidence that OeISY likely generates the monoterpene scaffold of oleuropein in olive fruits. OeISY, the first pathway gene characterized for this type of secoiridoid, is a potential target for breeding programs in a high value secoiridoid-accumulating species.
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