ReviewBiochimica et biophysica acta2016
Evaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methods.
Review in Biochimica et biophysica acta, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
- From Microscopy to Nanoscopy: Contemporary Physical Methods in Mitochondrial Structural Biology.International journal of molecular sciences · 2026Review
- Mitochondrial Dysfunction and Risk Factors for Noncommunicable Diseases: From Basic Concepts to Future Prospective.Diseases (Basel, Switzerland) · 2024Review
- Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women.Obesity (Silver Spring, Md.) · 2024Article
- A systematic review of the relationship between muscle oxygen dynamics and energy rich phosphates. Can NIRS help?BMC sports science, medicine & rehabilitation · 2024Article
- From mitochondria to cells to humans: Targeting bioenergetics in aging and disease.The international journal of biochemistry & cell biology · 2023Article
- The Key Role of Mitochondrial Function in Health and Disease.Antioxidants (Basel, Switzerland) · 2023Review
- ATP and NADNutrients · 2023Article
- Attenuation of Neuromuscular Fatigue by Ischemic Preconditioning with Moderate Cuff Pressure is Not Related to Muscle Oxygen Saturation in Men.International journal of exercise science · 2023Article
- Article
- Article
- Effect of adipose tissue thickness and tissue optical properties on the differential pathlength factor estimation for NIRS studies on human skeletal muscle.Biomedical optics express · 2021Article
- Mitochondrial oncobioenergetics of prostate tumorigenesis.Oncology letters · 2019Review
- Time Domain Near Infrared Spectroscopy Device for Monitoring Muscle Oxidative Metabolism: Custom Probe and In Vivo Applications.Sensors (Basel, Switzerland) · 2018Article
- Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review.Quantitative imaging in medicine and surgery · 2017Review
- Skeletal muscle bioenergetics in aging and heart failure.Heart failure reviews · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is now clear that mitochondria are involved as either a cause or consequence of many chronic diseases. This central role of the mitochondria is due to their position in the cell as important integrators of cellular energetics and signaling. Mitochondrial function affects many aspects of the cellular environment such as redox homeostasis and calcium signaling, which then also exert control over mitochondrial function. This complex dynamic between mitochondrial function and the cellular environment highlights the value of examining mitochondria in vivo in the intact physiological environment. This review discusses NMR and optical approaches used to measure mitochondria ATP and oxygen fluxes that provide in vivo measures of mitochondrial capacity and quality in animal and human models. Combining these in vivo measurements with more traditional ex vivo analyses can lead to new insights into the importance of the cellular environment in controlling mitochondrial function under pathological conditions. Interpretation and underlying assumptions for each technique are discussed with the goal of providing an overview of some of the most common approaches used to measure in vivo mitochondrial function encountered in the literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.