ArticleNeuroscience2016
Topographic organizations of taste-responsive neurons in the parabrachial nucleus of C57BL/6J mice: An electrophysiological mapping study.
Article in Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Mapping Fos-immunoreactive neurons activated by intra-oral infusion of quinine, sucrose or water throughout the brain of B6 mice.Brain structure & function · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- ParabrachialeNeuro · 2025Article
- Feeding signals inhibit fluid-satiation signals in the mouse lateral parabrachial nucleus to increase intake of highly palatable, caloric solutions.Journal of neurochemistry · 2023Article
- A Novel Mechanism for T1R-Independent Taste Responses to Concentrated Sugars.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- TRPV1-Lineage Somatosensory Fibers Communicate with Taste Neurons in the Mouse Parabrachial Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Satb2 neurons in the parabrachial nucleus mediate taste perception.Nature communications · 2021Article
- Functional and Neurochemical Identification of Ghrelin Receptor (GHSR)-Expressing Cells of the Lateral Parabrachial Nucleus in Mice.Frontiers in neuroscience · 2021Article
- Chemospecific deficits in taste sensitivity following bilateral or right hemispheric gustatory cortex lesions in rats.The Journal of comparative neurology · 2020Article
- The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity.Cellular and molecular life sciences : CMLS · 2020Review
- Two neuronal groups for NaCl with differential taste response properties and topographical distributions in the rat parabrachial nucleus.Physiological reports · 2020Article
- Sweet and bitter taste stimuli activate VTA projection neurons in the parabrachial nucleus.Brain research · 2019Article
- Mouse Parabrachial Neurons Signal a Relationship between Bitter Taste and Nociceptive Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- Central taste anatomy and physiology.Handbook of clinical neurology · 2019Review
- The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm.Trends in neurosciences · 2018Review
- Salt Appetite, and the Influence of Opioids.Neurochemical research · 2018Review
- Overlapping Representation of Primary Tastes in a Defined Region of the Gustatory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- 5-HTThe Journal of comparative neurology · 2017Article
- Post-oral sugar detection rapidly and chemospecifically modulates taste-guided behavior.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The activities of 178 taste-responsive neurons were recorded extracellularly from the parabrachial nucleus (PbN) in the anesthetized C57BL/6J mouse. Taste stimuli included those representative of five basic taste qualities, sweet, salty, sour, bitter and umami. Umami synergism was represented by all sucrose-best and sweet-sensitive sodium chloride-best neurons. Mediolaterally the PbN was divided into medial, brachium conjunctivum (BC) and lateral subdivisions while rostrocaudally the PbN was divided into rostral and caudal subdivisions for mapping and reconstruction of recording sites. Neurons in the medial and BC subdivisions had a significantly greater magnitude of response to sucrose and to the mixture of monopotassium glutamate and inosine monophosphate than those found in the lateral subdivision. In contrast, neurons in the lateral subdivision possessed a more robust response to quinine hydrochloride. Rostrocaudally no difference was found in the mean magnitude of response. Analysis on the distribution pattern of neuron types classified by their best stimulus revealed that the proportion of neuron types in the medial vs. lateral and BC vs. lateral subdivisions was significantly different, with a greater amount of sucrose-best neurons found medially and within the BC, and a greater amount of sodium chloride-, citric acid- and quinine hydrochloride-best neurons found laterally. There was no significant difference in the neuron-type distribution between rostral and caudal PbN. We also assessed breadth of tuning in these neurons by calculating entropy (H) and noise-to-signal (N/S) ratio. The mean N/S ratio of all neurons (0.43) was significantly lower than that of H value (0.64). Neurons in the caudal PbN had a significantly higher H value than in the rostral PbN. In contrast, mean N/S ratios were not different both mediolaterally and rostrocaudally. These results suggest that although there is overlap in taste quality representation in the mouse PbN, taste-responsive neurons still possessed a topographic organization.
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