ArticleJournal of the International Neuropsychological Society : JINS2016
Lower Working Memory Performance in Overweight and Obese Adolescents Is Mediated by White Matter Microstructure.
Article in Journal of the International Neuropsychological Society : JINS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Executive Functions in Overweight and Obesity: A Systematic Review of Neuropsychological Cross-Sectional and Longitudinal Studies.Frontiers in psychology · 2019Pooled it
- Executive and Reward-Related Function in Pediatric Obesity: A Meta-Analysis.Childhood obesity (Print) · 2018Pooled it
- Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.The Cochrane database of systematic reviews · 2018Pooled it
- Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.The Cochrane database of systematic reviews · 2018Pooled it
- Central Obesity-related Brain Alterations Predict Cognitive Impairments in First Episode of Psychosis.Schizophrenia bulletin · 2026Observational
- Neurophysiological and executive function differences among underweight, overweight, and normal-weight children and adolescents.Pediatric research · 2026Article
- Nonlinear associations between body mass index and brain microstructure across adolescence in the ABCD Study.bioRxiv : the preprint server for biology · 2026Article
- Obesity as a catalyst for neurodegeneration.Nature metabolism · 2026Review
- Two types of Wechsler Adult Intelligence Scale (WAIS) index discrepancies are associated with insufficient weight reduction after sleeve gastrectomy in adult patients with obesity: a retrospective study.European journal of medical research · 2026Article
- Structural and Functional Brain Changes in Children and Adolescents With Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Neural Correlates Underlying General and Food-Related Working Memory in Females with Overweight/Obesity.Nutrients · 2025Article
- Article
- Interplay between preclinical indices of obesity and neural signatures of fluid intelligence in youth.Communications biology · 2024Article
- Association between telomere length and neuropsychological function at 4-5 years in children from the INMA project: a cross-sectional study.European child & adolescent psychiatry · 2024Article
- Structural Connectivity between Olfactory Tubercle and Ventrolateral Periaqueductal Gray Implicated in Human Feeding Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The Relationship between Executive Functions and Body Weight: Sex as a Moderating Variable.Behavioral sciences (Basel, Switzerland) · 2024Article
- Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities.FEBS open bio · 2024Review
- Threshold effects of sleep duration and cognitive function in older adults with BMI ≥ 25 kg/mFrontiers in aging neuroscience · 2024Article
- Review
- The interconnection between obesity and executive function in adolescence: The role of the gut microbiome.Neuroscience and biobehavioral reviews · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectivesElevated body mass index (BMI) is associated with deficits in working memory, reduced gray matter volume in frontal and parietal lobes, as well as changes in white matter (WM) microstructure. The current study examined whether BMI was related to working memory performance and blood oxygen level dependent (BOLD) activity, as well as WM microstructure during adolescence.
methodsLinear regressions with BMI and (1) verbal working memory BOLD signal, (2) spatial working memory BOLD signal, and (3) fractional anisotropy (FA), a measure of WM microstructure, were conducted in a sample of 152 healthy adolescents ranging in BMI.
resultsBMI was inversely related to IQ and verbal and spatial working memory accuracy; however, there was no significant relationship between BMI and BOLD response for either verbal or spatial working memory. Furthermore, BMI was negatively correlated with FA in the left superior longitudinal fasciculus (SLF) and left inferior longitudinal fasciculus (ILF). ILF FA and IQ significantly mediated the relationship between BMI and verbal working memory performance, whereas SLF FA, but not IQ, significantly mediated the relationship between BMI and accuracy of both verbal and spatial working memory.
conclusionsThese findings indicate that higher BMI is associated with decreased FA in WM fibers connecting brain regions that support working memory, and that WM microstructural deficits may underlie inferior working memory performance in youth with higher BMI. Of interest, BMI did not show the same relationship with working memory BOLD activity, which may indicate that changes in brain structure precede changes in function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.