Evidence map›Paper›PMID 26708292›Full record

ReviewCellular and molecular life sciences : CMLS2016

NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions.

Nidhi Sharma, Sushmita Jha

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Intestinal microbiota: a new force in cancer immunotherapy.Cell communication and signaling : CCS · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nidhi SharmaDepartment of Biology, Indian Institute of Technology Jodhpur, Old Residency Road, Ratanada, Jodhpur, Rajasthan, 342011, India.
Sushmita JhaDepartment of Biology, Indian Institute of Technology Jodhpur, Old Residency Road, Ratanada, Jodhpur, Rajasthan, 342011, India. sushmitajha@gmail.com.ORCID http://orcid.org/0000-0003-2336-5064

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NLRs (nucleotide-binding domain, leucine-rich repeat containing receptors) are pattern recognition receptors associated with immunity and inflammation in response to endogenous and exogenous pathogen and damage associated molecular patterns (PAMPs and DAMPs respectively). Dysregulated NLR function is associated with several diseases including cancers, metabolic diseases, autoimmune disorders and autoinflammatory syndromes. In the last decade, distinct cell and organ specific roles for NLRs have been identified however; their roles in cancer initiation, development and progression remain controversial. This review summarizes the emerging role of NLRs in cancer and their possible future as targets for cancer therapeutics.

Indexed as

Adaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsDNA-Binding ProteinsHumansInflammasomesIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsNeoplasmsNeuronal Apoptosis-Inhibitory ProteinNLR ProteinsAdaptor Proteins, Signal TransducingAIM2 protein, humanApoptosis Regulatory ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsDNA-Binding ProteinsInflammasomesIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsNAIP protein, humanNeuronal Apoptosis-Inhibitory ProteinNLRC3 protein, humanNLRC4 protein, humanNLRP1 protein, humanNLRP6 protein, humanNLR ProteinsASCCaspaseInflammasomesInnate immunityInterleukinsTherapeuticsTumor microenvironment

Identifiers

PMID26708292
PMCPMC11108278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.