Evidence map›Paper›PMID 26707990›Full record

ReviewOsteoarthritis and cartilage2016

Osteoarthritis year in review 2015: mechanics.

N H Varady, A J Grodzinsky

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. MMPs in tissues retrieved during surgery from patients with TMJ disorders relate to pain more than to radiological damage score.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

N H VaradyDepartment of Mechanical Engineering, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
A J GrodzinskyDepartment of Mechanical Engineering, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Department of Biological Engineering, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Department of Electrical Engineering & Computer Science, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: alg@mit.edu.
IIT@MIT · US

Funding

MECHANISMS OF CHONDROCYTE RESPONSE TO MECHANICAL STIMULIR01AR045779 · NIAMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRODZINSKY, ALAN J. · 1998 to 2008
$2.1M
Cartilage Repair Using Self Assembling Peptide ScaffoldsR01AR060331 · NIAMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRODZINSKY, ALAN J. · 2012 to 2016
$1.7M
ELECTROMECHANICS OF CARTILAGE: SYNTHESIS &DEGRADATIIONR01AR033236 · NIAMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRODZINSKY, ALAN J. · 1986 to 2010
$1.5M
NIAMS NIH HHS AR060331NIAMS NIH HHS R01 AR033236NIAMS NIH HHS R01 AR045779NIAMS NIH HHS R01 AR060331
6 · The paper itself

Abstract

Motivated by the conceptual framework of multi-scale biomechanics, this narrative review highlights recent major advances with a focus on gait and joint kinematics, then tissue-level mechanics, cell mechanics and mechanotransduction, matrix mechanics, and finally the nanoscale mechanics of matrix macromolecules. A literature review was conducted from January 2014 to April 2015 using PubMed to identify major developments in mechanics related to osteoarthritis (OA). Studies of knee adduction, flexion, rotation, and contact mechanics have extended our understanding of medial compartment loading. In turn, advances in measurement methodologies have shown how injuries to both the meniscus and ligaments, together, can alter joint kinematics. At the tissue scale, novel findings have emerged regarding the mechanics of the meniscus as well as cartilage superficial zone. Moving to the cell level, poroelastic and poro-viscoelastic mechanisms underlying chondrocyte deformation have been reported, along with the response to osmotic stress. Further developments have emerged on the role of calcium signaling in chondrocyte mechanobiology, including exciting findings on the function of mechanically activated cation channels newly found to be expressed in chondrocytes. Finally, AFM-based nano-rheology systems have enabled studies of thin murine tissues and brush layers of matrix molecules over a wide range of loading rates including high rates corresponding to impact injury. With OA acknowledged to be a disease of the joint as an organ, understanding mechanical behavior at each length scale helps to elucidate the connections between cell biology, matrix biochemistry and tissue structure/function that may play a role in the pathomechanics of OA.

Indexed as

AnimalsBiomechanical PhenomenaCalcium SignalingCartilage, ArticularChondrocytesElasticityGaitHumansJointsKnee JointMechanotransduction, CellularMenisci, TibialMiceNanotechnologyOsteoarthritisOsteoarthritis, KneeAFM-NanoindentationCell mechanicsJoint kinematicsMechanotransductionMolecular mechanicsTissue mechanics

Identifiers

PMID26707990
PMCPMC4693146
OpenAlexW2212681443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.