ArticleCritical care (London, England)2015
Fluid overload and acute kidney injury: cause or consequence?
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between fluid overload and mortality in newborns: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 : Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine.Intensive care medicine · 2017Pooled it
- Comparison of fluid balance and hemodynamic and metabolic effects of sodium lactate versus sodium bicarbonate versus 0.9% NaCl in porcine endotoxic shock: a randomized, open-label, controlled study.Critical care (London, England) · 2017Trial
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Time from acute kidney injury to continuous renal replacement therapy and outcomes in critically ill children.Clinical kidney journal · 2026Article
- Distinct 72-hour fluid balance trajectories are associated with 28-day mortality in a multicenter cohort of sepsis patients.Scientific reports · 2026Observational
- Transfusion-associated capillary leak in cardiac surgery is linked to adverse postoperative outcomes: a prospective observational study.Annals of intensive care · 2026Article
- A review of enhanced recovery after surgery in kidney and liver transplantation and outline of the Newcastle ERAS protocols.Frontiers in transplantation · 2026Review
- Research advances on acute kidney injury and brain dysfunction.Frontiers in nephrology · 2026Review
- Renal congestion syndrome in critically ill patients: a neglected mechanism of acute kidney injury - A narrative review.Annals of intensive care · 2026Review
- Dietary methionine deprivation enhances renal resilience against ischemia-reperfusion injury in mice through modulation of glucose oxidation.Communications biology · 2025Article
- Association between intraoperative fluid management and postoperative outcomes in living kidney donors: a retrospective cohort study.Scientific reports · 2025Article
- Article
- Fluid accumulation in critically ill children: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Influence of fluid accumulation on major adverse kidney events in critically ill patients - an observational cohort study.Annals of intensive care · 2024Article
- The effect of dehydration, hyperchloremia and volume of fluid resuscitation on acute kidney injury in children admitted to hospital with diabetic ketoacidosis.Pediatric nephrology (Berlin, Germany) · 2024Article
- Current Fluid Management Practice in Critically Ill Adults on Continuous Renal Replacement Therapy: A Binational, Observational Study.Blood purification · 2024Observational
- Nutritional and clinical factors associated with acute kidney injury development in critically ill children.Journal of nephrology · 2023Article
- Electronic alert outpatient protocol improves the quality of care for the risk of postcontrast acute kidney injury following computed tomography.Kidney research and clinical practice · 2023Article
- Clinical Features and Outcomes of Acute Kidney Injury in Critically Ill COVID-19 Patients: A Retrospective Observational Study.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence that fluid overload and acute kidney injury (AKI) are associated but the exact cause-effect relationship remains unclear. Wang and colleagues analysed patients admitted to 30 intensive care units in China and found that fluid accumulation was independently associated with an increased risk of AKI and mortality. This commentary focuses on the close pathophysiological link between AKI and fluid overload and discusses the implications for clinical practice. It outlines some of the challenges, including the difficulty in diagnosing fluid overload reliably with current methods, and stresses the importance of personalised fluid therapy with physiological end-points to avoid the deleterious effects of fluid overload.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.