Evidence map›Paper›PMID 26707820›Full record

ReviewNanomedicine : nanotechnology, biology, and medicine2016

Biological interactions of carbon-based nanomaterials: From coronation to degradation.

Kunal Bhattacharya, Sourav P Mukherjee, Audrey Gallud, Seth C Burkert, Silvia Bistarelli, Stefano Bellucci, Massimo Bottini, Alexander Star, Bengt Fadeel

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nanomedicine : nanotechnology, biology, and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed.

  1. Review
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  13. Single Atom Engineered Antibiotics Overcome Bacterial Resistance.Advanced materials (Deerfield Beach, Fla.) · 2024
    Article
  14. Review
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  16. Article
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58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kunal BhattacharyaDivision of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Sourav P MukherjeeDivision of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Audrey GalludDivision of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Seth C BurkertDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.
Silvia BistarelliNational Institute of Nuclear Physics-INFN, Frascati, Province of Rome, Italy.
Stefano BellucciNational Institute of Nuclear Physics-INFN, Frascati, Province of Rome, Italy.
Massimo BottiniDepartment of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome, Italy; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
Alexander StarDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA.
Bengt FadeelDivision of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: bengt.fadeel@ki.se.

Funding

Investigations and Mitigation of Carbon Nanomaterial ToxicityR01ES019304 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STAR, ALEXANDER · 2010 to 2014
$1.9M
NIEHS NIH HHS R01 ES019304NIEHS NIH HHS R01ES019304
6 · The paper itself

Abstract

Carbon-based nanomaterials including carbon nanotubes, graphene oxide, fullerenes and nanodiamonds are potential candidates for various applications in medicine such as drug delivery and imaging. However, the successful translation of nanomaterials for biomedical applications is predicated on a detailed understanding of the biological interactions of these materials. Indeed, the potential impact of the so-called bio-corona of proteins, lipids, and other biomolecules on the fate of nanomaterials in the body should not be ignored. Enzymatic degradation of carbon-based nanomaterials by immune-competent cells serves as a special case of bio-corona interactions with important implications for the medical use of such nanomaterials. In the present review, we highlight emerging biomedical applications of carbon-based nanomaterials. We also discuss recent studies on nanomaterial 'coronation' and how this impacts on biodistribution and targeting along with studies on the enzymatic degradation of carbon-based nanomaterials, and the role of surface modification of nanomaterials for these biological interactions. FROM THE CLINICAL EDITOR: Advances in technology have produced many carbon-based nanomaterials. These are increasingly being investigated for the use in diagnostics and therapeutics. Nonetheless, there remains a knowledge gap in terms of the understanding of the biological interactions of these materials. In this paper, the authors provided a comprehensive review on the recent biomedical applications and the interactions of various carbon-based nanomaterials.

Indexed as

NanostructuresAnimalsBiocatalysisBiocompatible MaterialsCarbonFullerenesGraphiteHumansLipid MetabolismModels, MolecularNanotubes, CarbonOxidesProtein CoronaBiocompatible MaterialsCarbonFullerenesGraphiteNanotubes, CarbonOxidesProtein CoronaBio-coronaBiodegradationCarbon nanotubesFullerenesGraphene oxideNanodiamonds

Identifiers

PMID26707820
PMCPMC4789123

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.