Evidence map›Paper›PMID 26707739›Full record

ReviewCurrent opinion in microbiology2016

Commensal 'trail of bread crumbs' provide pathogens with a map to the intestinal landscape.

Deborah H Luzader, Melissa M Kendall

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Ethanolamine-induced assembly of microcompartments is required forbioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. The sRNA DicF integrates oxygen sensing to enhance enterohemorrhagicProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Deborah H LuzaderDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, 1340 Jefferson Park Ave., Charlottesville, VA 22908, USA.
Melissa M KendallDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, 1340 Jefferson Park Ave., Charlottesville, VA 22908, USA. Electronic address: melissakendall@virginia.edu.

Funding

Global Biothreats Training ProgramT32AI055432 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CRISS, ALISON K, PETRI, WILLIAM A · 2003 to 2022
$4.0M
Ethanolamine Signaling in Virulence Gene Regulation and Host/Microbial InteractionsR01AI118732 · NIAID · UNIVERSITY OF VIRGINIA · PI KENDALL, MELISSA · 2015 to 2019
$1.9M
NIAID NIH HHS 5 T32 AI055432NIAID NIH HHS R01 AI118732NIAID NIH HHS R01AI118732NIAID NIH HHS T32 AI055432
6 · The paper itself

Abstract

Growth of a microorganism in a host is essential for infection, and bacterial pathogens have evolved to utilize specific metabolites to enhance replication in vivo. Now, emerging data demonstrate that pathogens rely on microbiota-derived metabolites as a form of bacterial-bacterial communication to gain information about location within a host and modify virulence gene expression accordingly. Thus, metabolite-sensing is critical for pathogens to establish infection. Here, we highlight recent examples of how the foodborne pathogen enterohemorrhagic Escherichia coli O157:H7 (EHEC) exploits microbiota-derived metabolites to recognize the host intestinal environment and control gene expression that results in controlled expression of virulence traits.

Indexed as

Microbial InteractionsAnimalsEscherichia coli InfectionsEscherichia coli O157Escherichia coli ProteinsEthanolamineGastrointestinal MicrobiomeGene Expression Regulation, BacterialHost-Pathogen InteractionsHumansIntestinal MucosaIntestinesMiceTNF-Related Apoptosis-Inducing LigandVirulenceEscherichia coli ProteinsEthanolamineTNF-Related Apoptosis-Inducing LigandTNFSF10 protein, human

Identifiers

PMID26707739
PMCPMC4755895

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.