ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Medication Regimen Complexity and Number of Medications as Factors Associated With Unplanned Hospitalizations in Older People: A Population-based Cohort Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Pooled it
- Patients' perspectives and experiences regarding medication reviews: A cross-sectional survey study.Exploratory research in clinical and social pharmacy · 2026Article
- New horizons in advancing lifestyle medicine for older adults utilizing a transdisciplinary approach: gaps and opportunities.Age and ageing · 2025Review
- Medication regimen complexity in cancer patients: an overlooked issue for healthcare team.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- The association between medication use and health-related quality of life in multimorbid older patients with polypharmacy.European geriatric medicine · 2024Article
- Complexity of the Therapeutic Regimen in Older Adults with Cancer: Associated Factors.Pharmaceuticals (Basel, Switzerland) · 2024Article
- A Prospective Study of the Medication Regimen Complexity Index and Hospitalization Due to Adverse Drug Reactions Among People Living with HIV.Medicina (Kaunas, Lithuania) · 2024Article
- Analyzing the Iatrogenic Triad: Discovering Strategies for Preventing Harm in the Elderly.Turkish journal of pharmaceutical sciences · 2024Article
- Knowledge and acceptance associated with medication adherence among hypertension individuals in Aceh province, Indonesia.Heliyon · 2024Article
- Polypharmacy Is Associated with Sociodemographic Factors and Socioeconomic Status in United States Adults.Pharmacy (Basel, Switzerland) · 2024Article
- Evaluating the Medication Regimen Complexity Score as a Predictor of Clinical Outcomes in the Critically Ill.Journal of clinical medicine · 2022Article
- Machine learning for predicting readmission risk among the frail: Explainable AI for healthcare.Patterns (New York, N.Y.) · 2022Article
- Medication Regimen Complexity and Medication Burden Among Patients With Type 2 Diabetes Mellitus: A Retrospective Analysis.Frontiers in pharmacology · 2022Article
- Methodological Challenges for Epidemiologic Studies of Deprescribing at the End of Life.Current epidemiology reports · 2021Article
- PRN Medicines Management for Older People with Long-Term Mental Health Disorders in Home Care.Risk management and healthcare policy · 2021Review
- Computational Approaches for Supporting Combination Therapy in the Post-Aducanumab Era in Alzheimer's Disease.Journal of Alzheimer's disease reports · 2021Review
- Associations of Medication Regimen Complexity with COPD Medication Adherence and Control.International journal of chronic obstructive pulmonary disease · 2021Article
- Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam.PloS one · 2021Article
- Interdisciplinary Mobile Health Model to Improve Clinical Care After Heart Transplantation: Implementation Strategy Study.JMIR cardio · 2020Article
- Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdverse drug events are a leading cause of hospitalization among older people. Up to half of all medication-related hospitalizations are potentially preventable. The objective of this study was to investigate and compare the association between medication regimen complexity and number of medications with unplanned hospitalizations over a 3-year period.
methodsData were analyzed for 3,348 participants aged 60 years or older in Sweden. Regimen complexity was assessed using the 65-item Medication Regimen Complexity Index (MRCI) and number of medications was assessed as a continuous variable. Cox proportional hazard models were used to compute unadjusted and adjusted hazard ratios with 95% confidence intervals (CIs) for associations between regimen complexity and number of medications with unplanned hospitalizations over a 3-year period. Receiver operating characteristics curves with corresponding areas under the curve were calculated for regimen complexity and number of medications in relation to unplanned hospitalizations. The population attributable fraction of unplanned hospitalizations was calculated for MRCI and number of medications.
resultsIn total, 1,125 participants (33.6%) had one or more unplanned hospitalizations. Regimen complexity (hazard ratio 1.22; 95% CI 1.14-1.34) and number of medications (hazard ratio 1.07; 95% CI 1.04-1.09) were both associated with unplanned hospitalizations and had similar sensitivity and specificity (area under the curve 0.641 for regimen complexity and area under the curve 0.644 for number of medications). The population attributable fraction was 14.08% (95% CI 9.62-18.33) for MRCI and 17.61% (95% CI 12.59-22.35) for number of medications.
conclusionsThere was no evidence that using a complex tool to assess regimen complexity was better at predicting unplanned hospitalization than number of medications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.