ReviewCurrent allergy and asthma reports2016
Cytokine Patterns and Endotypes in Acute and Chronic Rhinosinusitis.
Review in Current allergy and asthma reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Evaluating the Efficacy and Safety of a Nasal Medical Device (NESOSPRAY HE-G) in Acute Rhinosinusitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Medicina (Kaunas, Lithuania) · 2026Trial
- Alleviating symptoms of paediatric acute rhinosinusitis and acute otitis media with otorrhea using nasal-spraying Bacillus probiotics: a randomized controlled trial.Scientific reports · 2025Trial
- Immune Clues to Sinus Blues: Linking Biomarkers to Radiologic Score of Rhinosinusitis.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Effects of urban PM2.5 on primary sinonasal epithelial cells in individuals with chronic rhinosinusitis.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- MUC1 in the upper-lower airway inflammatory continuum: an endotype-centered perspective.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Inflammatory Molecule Elaboration in Secondhand Smoke (SHS)-Induced or Conditional RAGE Transgenic Modeling of Chronic Rhinosinusitis (CRS).Current issues in molecular biology · 2025Article
- Effects of inflammatory endotypes on disease trajectory in chronic rhinosinusitis with nasal polyps.The Journal of allergy and clinical immunology · 2025Article
- Label-Free Quantitative Proteomics Analysis of Nasal Lavage Fluid in Chronic Rhinosinusitis with Nasal Polyposis.Biology · 2024Article
- An Integrated Analysis of Inflammatory Endotypes and Clinical Characteristics in Chronic Rhinosinusitis with Nasal Polyps.Journal of inflammation research · 2022Article
- XBP1 Regulates the Transcription of HIF-1a in BALB/c Mice with Chronic Rhinosinusitis without Polyps.Analytical cellular pathology (Amsterdam) · 2022Article
- Chronic Rhinosinusitis and Alzheimer's Disease-A Possible Role for the Nasal Microbiome in Causing Neurodegeneration in the Elderly.International journal of molecular sciences · 2021Review
- Effects ofLaryngoscope investigative otolaryngology · 2021Article
- Expression of silent information regulator 1 in chronic rhinosinusitis and regulatory effects of inflammatory factors.International journal of clinical and experimental pathology · 2021Article
- Effects ofJournal of drug assessment · 2020Article
- Observational
- Current and Future Treatments of Rhinitis and Sinusitis.The journal of allergy and clinical immunology. In practice · 2020Review
- Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis.Allergy, asthma & immunology research · 2020Review
- Immunological Features of Paranasal Sinus Mucosa in Patients with Graves' Orbitopathy.Frontiers in endocrinology · 2020Article
- The multifaceted link between inflammation and human diseases.Journal of cellular physiology · 2018Review
- Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies.Microbiome · 2018Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since rhinosinusitis is an inflammatory disease, cytokines as key regulators of inflammation play a central role in its pathophysiology. In acute rhinosinusitis, several proinflammatory cytokines of different types have been identified. Initial information about the involvement of the inflammasome in rhinosinusitis has been gained, but this area remains open for more detailed research. Although it has been accepted now that chronic rhinosinusitis (CRS) needs to be differentiated into CRS with and without nasal polyps, it has become clear that this distinction is insufficient to clearly define subgroups with uniform pathophysiology and cytokine patterns. While Th1-cytokines are mostly found in CRSsNP and Th2 cytokines in CRSwNP, there is a substantial overlap, and several other cytokines have also been detected. Attempts to identify CRS endotypes based on cytokines are ongoing but not yet generally accepted. Despite the central role of cytokines in rhinosinusitis, no specific cytokine-targeted therapies are currently available, and only very few studies have specifically addressed the effects of such biologicals in rhinosinusitis.
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