ArticleAnnals of emergency medicine2016
Confronting Ethical and Regulatory Challenges of Emergency Care Research With Conscious Patients.
Article in Annals of emergency medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Acceptability of ambulance-based telemedicine (ABT) for paediatric emergencies in Karachi, Pakistan.BMJ global health · 2026Article
- Patient-Reported Symptoms of Acute Coronary Syndrome in the Prehospital Period in a Prospective Study: Implications for Emergency Nurse Triage, Diagnosis, and Clinical Outcomes.Journal of emergency nursing · 2025Article
- Perceptions of consent for a paediatric telehealth trial during emergency transport in Pakistan.Archives of disease in childhood · 2025Article
- Advance consent for participation in randomised controlled trials for emergency conditions: a scoping review.BMJ open · 2023Article
- Clinical presentation in EMS patients with acute chest pain in relation to sex, age and medical history: prospective cohort study.BMJ open · 2022Observational
- The ethical considerations for emergency care research in low- and middle-income countries: A scoping review of the published literature.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2022Article
- Ethical Considerations in Clinical Trials for Disorders of Consciousness.Brain sciences · 2022Article
- The acceptability of delayed consent for prehospital emergency care research in the Western Cape province of South Africa.PloS one · 2022Article
- Exception from informed consent for biomedical research in emergency settings: A study from Jordan.Heliyon · 2021Article
- Motivation to participate and experiences of the informed consent process for randomized clinical trials in emergency obstetric care in Uganda.BMC medical ethics · 2021Article
- Observational
- Advanced consent for participation in acute care randomised control trials: protocol for a scoping review.BMJ open · 2020Article
- [Empirical health services research in emergency and acute medicine : Preliminary results of concomitant monitoring of patient recruitment and sample quality].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Article
- Determinants of Patient and Surrogate Experiences With Acute Care Research Consent: A Key Informant Interview Study.Journal of the American Heart Association · 2019Article
- Ethical tensions in the informed consent process for randomized clinical trials in emergency obstetric and newborn care in low and middle-income countries.BMC medical ethics · 2019Article
- Emergency Consent: Patients' and Surrogates' Perspectives on Consent for Clinical Trials in Acute Stroke and Myocardial Infarction.Journal of the American Heart Association · 2019Article
- Emergency care research as a global health priority: key scientific opportunities and challenges.BMJ global health · 2019Review
- Emergency care research ethics in low-income and middle-income countries.BMJ global health · 2019Review
- Understanding preferences regarding consent for pragmatic trials in acute care.Clinical trials (London, England) · 2018Article
- Capacity, Vulnerability, and Informed Consent for Research.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Barriers to informed consent are ubiquitous in the conduct of emergency care research across a wide range of conditions and clinical contexts. They are largely unavoidable; can be related to time constraints, physical symptoms, emotional stress, and cognitive impairment; and affect patients and surrogates. US regulations permit an exception from informed consent for certain clinical trials in emergency settings, but these regulations have generally been used to facilitate trials in which patients are unconscious and no surrogate is available. Most emergency care research, however, involves conscious patients, and surrogates are often available. Unfortunately, there is neither clear regulatory guidance nor established ethical standards in regard to consent in these settings. In this report-the result of a workshop convened by the National Institutes of Health Office of Emergency Care Research and Department of Bioethics to address ethical challenges in emergency care research-we clarify potential gaps in ethical understanding and federal regulations about research in emergency care in which limited involvement of patients or surrogates in enrollment decisions is possible. We propose a spectrum of approaches directed toward realistic ethical goals and a research and policy agenda for addressing these issues to facilitate clinical research necessary to improve emergency care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.