Evidence map›Paper›PMID 26706784›Full record

ReviewPharmacological research2016

Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.

Bryan L Copple, Tiangang Li

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacological research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.

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  7. Dysbiosis in the Gut-Liver Axis Is Associated With Low Bone Mass During Murine Cholestasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Bryan L CoppleDepartment of Pharmacology and Toxicology, B403 Life Sciences Building, Michigan State University, East Lansing, MI 48824, United States. Electronic address: copple@msu.edu.
Tiangang LiDepartment of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States.
Michigan State University · USUniversity of Kansas Medical Center · US

Funding

Role of Early Growth Response Factor-1 in Cholestatic Liver InjuryR01DK073566 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI COPPLE, BRYAN L · 2007 to 2017
$2.4M
The role of hepatic Sortlin 1 in diabetic dyslipidemiaR01DK102487 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LI, TIANGANG · 2014 to 2018
$1.6M
NIDDK NIH HHS 1 R01 DK102487-01NIDDK NIH HHS 2 R01 DK073566-07NIDDK NIH HHS R01 DK073566NIDDK NIH HHS R01 DK102487
6 · The paper itself

Abstract

For many years, bile acids were thought to only function as detergents which solubilize fats and facilitate the uptake of fat-soluble vitamins in the intestine. Many early observations; however, demonstrated that bile acids regulate more complex processes, such as bile acids synthesis and immune cell function through activation of signal transduction pathways. These studies were the first to suggest that receptors may exist for bile acids. Ultimately, seminal studies by many investigators led to the discovery of several bile acid-activated receptors including the farnesoid X receptor, the vitamin D receptor, the pregnane X receptor, TGR5, α5 β1 integrin, and sphingosine-1-phosphate receptor 2. Several of these receptors are expressed outside of the gastrointestinal system, indicating that bile acids may have diverse functions throughout the body. Characterization of the functions of these receptors over the last two decades has identified many important roles for these receptors in regulation of bile acid synthesis, transport, and detoxification; regulation of glucose utilization; regulation of fatty acid synthesis and oxidation; regulation of immune cell function; regulation of energy expenditure; and regulation of neural processes such as gastric motility. Through these many functions, bile acids regulate many aspects of digestion ranging from uptake of essential vitamins to proper utilization of nutrients. Accordingly, within a short time period, bile acids moved beyond simple detergents and into the realm of complex signaling molecules. Because of the important processes that bile acids regulate through activation of receptors, drugs that target these receptors are under development for the treatment of several diseases, including cholestatic liver disease and metabolic syndrome. In this review, we will describe the various bile acid receptors, the signal transduction pathways activated by these receptors, and briefly discuss the physiological processes that these receptors regulate.

Indexed as

AnimalsBile Acids and SaltsHumansReceptors, Cytoplasmic and NuclearSignal TransductionBile Acids and SaltsReceptors, Cytoplasmic and NuclearBile acidsFarnesoid X receptorPregnane X receptorSphingosine-1-phosphate receptor 2TGR5Vitamin D receptor

Identifiers

PMID26706784
PMCPMC4900180
OpenAlexW2208262108

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.