Evidence map›Paper›PMID 26706699›Full record

ArticleOsteoarthritis and cartilage2016

Are unilateral and bilateral knee osteoarthritis patients unique subsets of knee osteoarthritis? A biomechanical perspective.

S P Messier, D P Beavers, C Herman, D J Hunter, P DeVita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S P MessierDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA; Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Rheumatology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: messier@wfu.edu.
D P BeaversDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
C HermanDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA.
D J HunterRheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.
P DeVitaDepartment of Kinesiology, East Carolina University, Greenville, NC, USA.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
USE OF MOTIVATIONAL INTERVIEWING TO MANAGE TYPE I DIABETESM01RR000211 · NCRR · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HAK, EMILY B · 1985 to 2006
$9.6M
Intensive Dietary Restriction with Exercise in ArthritisR01AR052528 · NIAMS · WAKE FOREST UNIVERSITY · PI MESSIER, STEPHEN P · 2006 to 2010
$2.9M
NCRR NIH HHS M01 RR000211NCRR NIH HHS M01 RR00211NIAMS NIH HHS R01 AR052528NIAMS NIH HHS R01 AR052528-01NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG21332
6 · The paper itself

Abstract

objectiveTo compare the gait of adults with unilateral and bilateral symptomatic and radiographic knee osteoarthritis (OA) to determine whether these subgroups can be treated similarly in the clinic and when recruiting for randomized clinical trials, and to use these data to generate future hypotheses regarding gait in these subsets of knee OA patients.

methodsCross-sectional investigation of patients with unilateral and bilateral knee OA on gait mechanics using 136 older adults (age ≥55 yrs; 27 kg m(-2) ≥ BMI ≤ 41 kg m(-2); 82% female) with radiographic knee OA. Comparisons were made between the most affected side of the bilateral group (Bi) and the affected side of the unilateral group (Uni), and between symmetry indices of each group.

resultsThere were no significant differences in any temporal, kinematic, or kinetic measures between the Uni and Bi cohorts. Comparison of symmetry indices between groups also revealed no significant differences.

conclusionThe similarity in lower extremity mechanics between unilateral and bilateral knee OA patients is sufficiently robust to consider both subsets as a single cohort. We hypothesize that biomechanical adaptations to knee OA are at least partially systemic in origin and not based solely on the physiological characteristics of an affected knee joint.

Indexed as

AgedAnkle JointBiomechanical PhenomenaBody Mass IndexCross-Sectional StudiesFemaleGaitHumansKnee JointMaleMiddle AgedOsteoarthritis, KneePain MeasurementRadiographyRange of Motion, ArticularSeverity of Illness IndexBiomechanicsGait symmetryKnee osteoarthritis

Identifiers

PMID26706699
PMCPMC4838498

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.