Evidence map›Paper›PMID 26706598›Full record

ArticleNeurobiology of disease2016

Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure.

Heather O'Leary, Paul B Bernard, Anna M Castano, Tim A Benke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Neonatal Seizures Revisited.Children (Basel, Switzerland) · 2021
    Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Heather O'LearyDepartment of Pediatrics, University of Colorado, School of Medicine, 80045, USA.
Paul B BernardDepartment of Pediatrics, University of Colorado, School of Medicine, 80045, USA.
Anna M CastanoDepartment of Pediatrics, University of Colorado, School of Medicine, 80045, USA.
Tim A BenkeDepartment of Pediatrics, University of Colorado, School of Medicine, 80045, USA; Department of Neurology, University of Colorado, School of Medicine, 80045, USA; Department of Pharmacology, University of Colorado, School of Medicine, 80045, USA; Department of Otolaryngology, University of Colorado, School of Medicine, 80045, USA; Neuroscience Graduate Program, University of Colorado, School of Medicine, 80045, USA. Electronic address: Tim.Benke@ucdenver.edu.
University of Colorado Denver · US

Funding

Development of Psychopathology, Psychobiology, & BehaviorT32MH015442 · NIMH · UNIVERSITY OF COLORADO DENVER · PI JASON R TREGELLAS · 1985 to 2026
$10.2M
Molecular mechanisms linking early life seizures, autism and intellectual disabilR01NS076577 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BENKE, TIMOTHY A · 2011 to 2015
$1.6M
NIMH NIH HHS T32 MH015442NIMH NIH HHS T32 MH15442-36NINDS NIH HHS R01 NS076577
6 · The paper itself

Abstract

Neonatal seizures are associated with long term disabilities including epilepsy and cognitive deficits. Using a neonatal seizure rat model that does not develop epilepsy, but develops a phenotype consistent with other models of intellectual disability (ID) and autism spectrum disorders (ASD), we sought to isolate the acute effects of a single episode of early life seizure on hippocampal CA1 synaptic development and plasticity. We have previously shown chronic changes in glutamatergic synapses, loss of long term potentiation (LTP) and enhanced long term depression (LTD), in the adult male rat ~50days following kainic acid (KA) induced early life seizure (KA-ELS) in post-natal (P) 7day old male Sprague-Dawley rats. In the present work, we examined the electrophysiological properties and expression levels of glutamate receptors in the acute period, 2 and 7days, post KA-ELS. Our results show for the first time enhanced LTP 7days after KA-ELS, but no change 2days post KA-ELS. Additionally, we report that ionotropic α-amino-3-hydroxy-5-methyl-isoxazole-propionic acid type glutamate receptor (AMPAR) desensitization is decreased in the same time frame, with no changes in AMPAR expression, phosphorylation, or membrane insertion. Inappropriate enhancement of the synaptic connections in the acute period after the seizure could alter the normal patterning of synaptic development in the hippocampus during this critical period and contribute to learning deficits. Thus, this study demonstrates a novel mechanism by which KA-ELS alters early network properties that potentially lead to adverse outcomes.

Indexed as

Acute DiseaseAnimalsAnimals, NewbornBlotting, WesternCA1 Region, HippocampalDisease Models, AnimalExcitatory Postsynaptic PotentialsKainic AcidLong-Term PotentiationMalePatch-Clamp TechniquesPhosphorylationPyramidal CellsRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateKainic AcidReceptors, AMPAReceptors, N-Methyl-D-AspartateAMPA receptorsAutismEarly life seizuresHippocampal dependent learningIntellectual disabilityLong term potentiationNMDA receptors

Identifiers

PMID26706598
PMCPMC4742248
OpenAlexW2200513201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.