ArticleMaterials science & engineering. C, Materials for biological applications2016
Chitosan-PLGA polymer blends as coatings for hydroxyapatite nanoparticles and their effect on antimicrobial properties, osteoconductivity and regeneration of osseous tissues.
Article in Materials science & engineering. C, Materials for biological applications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 102 citations in OpenAlex.
- Influence of carboxymethyl cellulose and calcium-crosslinked CMC coating of 3D-Printed hydroxyapatite scaffolds on the early hemostatic performance and osteoblastic compatibility.Frontiers in bioengineering and biotechnology · 2026Article
- Polymer- and Lipid-Based Nanostructures for Wound Healing with Barrier-Resolved Design.Pharmaceutics · 2025Review
- Chitosan-Hydrazone-Modified Calcium Phosphate Scaffolds: Fabrication, Characterization, and Drug Delivery Potential.Biomedicines · 2025Article
- Thermal Treatment and Polymer Matrix Diffusion Effects on Hydroxyapatite Particle Size Evolution.Polymers · 2025Article
- Doxycycline-Loaded pH-Sensitive Microparticles as a Potential Site-Specific Drug Delivery System against Periodontitis.ACS omega · 2025Article
- Fabrication and Characterization of Electrospun Sr/Zn-Doped Nano-Hydroxyapatite-Collagen-PLGA Nanofibrous Scaffolds for Bone Tissue Engineering.International journal of nanomedicine · 2025Article
- Formulation development, characterization, and optimization of Eudragit-cinnamon essential oil-based nanoplatform and its efficacy against resistant bacteria.Frontiers in chemistry · 2025Article
- Designing and the anticancer activity of chitosan and chitosan oligosaccharide lactate nanobeads loaded with Biginelli hybrid.RSC advances · 2024Article
- Chitosan modified with PAP as a promising delivery system for melatonin in the treatment of osteoporosis: targeting the divalent metal transporter 1.Journal of biological engineering · 2024Article
- Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction.Biomimetics (Basel, Switzerland) · 2024Review
- Tunable Release of Calcium from Chitosan-Coated Bioglass.Pharmaceutics · 2023Article
- Biomaterial composed of chitosan, riboflavin, and hydroxyapatite for bone tissue regeneration.Scientific reports · 2023Article
- Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration.Journal of functional biomaterials · 2022Article
- Bone Regeneration Using PEVAV/β-Tricalcium Phosphate Composite Scaffolds in Standardized Calvarial Defects: Micro-Computed Tomographic Experiment in Rats.Materials (Basel, Switzerland) · 2021Article
- Drug delivery nanocarriers and recent advances ventured to improve therapeutic efficacy against osteosarcoma: an overview.Journal of the Egyptian National Cancer Institute · 2021Review
- Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration.Polymers · 2020Review
- Use of nanoparticles in skeletal tissue regeneration and engineering.Histology and histopathology · 2020Review
- Effects of hydroxyapatite@poly-lactide-Toxicology research · 2019Article
- Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms.International journal of molecular sciences · 2019Review
- Composite Nanofibers Containing Multiwall Carbon Nanotubes as Biodegradable Membranes in Reconstructive Medicine.Nanomaterials (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Composite biomaterials comprising nanostructured hydroxyapatite (HAp) have an enormous potential for natural bone tissue reparation, filling and augmentation. Chitosan (Ch) as a naturally derived polymer has many physicochemical and biological properties that make it an attractive material for use in bone tissue engineering. On the other hand, poly-D,L-lactide-co-glycolide (PLGA) is a synthetic polymer with a long history of use in sustained drug delivery and tissue engineering. However, while chitosan can disrupt the cell membrane integrity and may induce blood thrombosis, PLGA releases acidic byproducts that may cause tissue inflammation and interfere with the healing process. One of the strategies to improve the biocompatibility of Ch and PLGA is to combine them with compounds that exhibit complementary properties. In this study we present the synthesis and characterization, as well as in vitro and in vivo analyses of a nanoparticulate form of HAp coated with two different polymeric systems: (a) Ch and (b) a Ch-PLGA polymer blend. Solvent/non-solvent precipitation and freeze-drying were used for synthesis and processing, respectively, whereas thermogravimetry coupled with mass spectrometry was used for phase identification purposes in the coating process. HAp/Ch composite particles exhibited the highest antimicrobial activity against all four microbial strains tested in this work, but after the reconstruction of the bone defect they also caused inflammatory reactions in the newly formed tissue where the defect had lain. Coating HAp with a polymeric blend composed of Ch and PLGA led to a decrease in the reactivity and antimicrobial activity of the composite particles, but also to an increase in the quality of the newly formed bone tissue in the reconstructed defect area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.