Evidence map›Paper›PMID 26705971›Full record

ArticleResuscitation2016

Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium.

Laurie J Morrison, Robert H Schmicker, Myron L Weisfeldt, Blair L Bigham, Robert A Berg, Alexis A Topjian, Beth L Abramson, Dianne L Atkins, Debra Egan, George Sopko and 2 more

Abstract readMulticenter Study
In one paragraph

Article in Resuscitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
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  4. Pediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Laurie J MorrisonRescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada; Division of Emergency Medicine; Department of Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada. Electronic address: morrisonl@smh.ca.
Robert H SchmickerClinical Trials Centre, University of Washington, WA, USA.
Myron L WeisfeldtJohns Hopkins Medicine, Baltimore, MD, USA.
Blair L BighamRescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Robert A BergThe Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Alexis A TopjianThe Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Beth L AbramsonCardiac Prevention Centre & Women's Cardiovascular Health, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Dianne L AtkinsUniversity of Iowa Children's Hospital, Carver College of Medicine, Iowa City, IA, USA.
Debra EganDivision of Cardiovascular Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
George SopkoDivision of Cardiovascular Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Valeria E RacInstitute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada; Toronto Health Economics and Technology Assessment Collaborative, Toronto General Research Insitute, University Health Network, and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
Resuscitation Outcomes Consortium Investigators
St. Michael's Hospital · CAChildren's Hospital of Philadelphia · USNational Institutes of Health · USJohns Hopkins University · USUniversity Health Network · CAUniversity of Iowa Stead Family Children’s Hospital · USUniversity of Washington · US

Funding

Resuscitation Outcomes Consortium (ROC) Data Coordinating CenterU01HL077863 · NHLBI · UNIVERSITY OF WASHINGTON · PI MAY, SUSANNE · 2004 to 2015
$125.1M
Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-PittsburghU01HL077871 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALLAWAY, CLIFTON W. · 2004 to 2015
$4.0M
Southeastern Resucitation Research CenterU01HL077881 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KERBY, JEFFREY D, WANG, HENRY E. · 2004 to 2015
$3.9M
Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-PortlandU01HL077873 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAYA, MOHAMUD RAMZANALI · 2004 to 2015
$3.9M
Resuscitation Outcomes Consortium Regional Clinical Center-DFW Center for ResusciU01HL077887 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI IDRIS, AHAMED H · 2004 to 2015
$3.2M
Resuscitation Outcomes Consortium (ROC) Regional Clinical Centers-MilwaukeeU01HL077866 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUFDERHEIDE, TOM PAUL · 2004 to 2015
$3.0M
Seattle-King County Center for Resuscitation ResearchU01HL077867 · NHLBI · UNIVERSITY OF WASHINGTON · PI KUDENCHUK, PETER JAMES · 2004 to 2015
$3.0M
The UCSD/San Diego Resuscitation Research CenterU01HL077908 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VILKE, GARY · 2004 to 2015
$2.9M
Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-OTTAWA-OPALS-BCRU01HL077885 · NHLBI · OTTAWA HOSPITAL RESEARCH INSTITUTE · PI STIELL, IAN G. · 2004 to 2015
$2.4M
Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-Toronto RegionalU01HL077872 · NHLBI · ST. MICHAEL'S HOSPITAL · PI MORRISON, LAURIE · 2004 to 2015
$1.9M
The Iowa Resuscitation Network:A Rural Regional Clin CtrU01HL077865 · NHLBI · UNIVERSITY OF IOWA · PI KERBER, RICHARD E · 2004 to 2007
$1.7M
Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac ArrestK23NS075363 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI TOPJIAN, ALEXIS A. · 2012 to 2016
$874k
Canadian Institutes of Health ResearchNHLBI NIH HHS 5U01 HL077863NHLBI NIH HHS HL077865NHLBI NIH HHS HL077866NHLBI NIH HHS HL077867NHLBI NIH HHS HL077871NHLBI NIH HHS HL077872NHLBI NIH HHS HL077873NHLBI NIH HHS HL077881NHLBI NIH HHS HL077885NHLBI NIH HHS HL077887NHLBI NIH HHS HL077908NHLBI NIH HHS U01 HL077863NHLBI NIH HHS U01 HL077865NHLBI NIH HHS U01 HL077866NHLBI NIH HHS U01 HL077867NHLBI NIH HHS U01 HL077871NHLBI NIH HHS U01 HL077872NHLBI NIH HHS U01 HL077873NHLBI NIH HHS U01 HL077881NHLBI NIH HHS U01 HL077885NHLBI NIH HHS U01 HL077887NHLBI NIH HHS U01 HL077908NINDS NIH HHS K23 NS075363
6 · The paper itself

Abstract

introductionThis study examined the relationship between gender and outcomes of non-traumatic out-of-hospital cardiac arrest (OHCA).

methodsAll eligible, consecutive, non-traumatic Emergency Medical Services (EMS) treated OHCA patients in the Resuscitation Outcomes Consortium between December 2005 and May 2007. Patient age was analyzed as a continuous variable and stratified in two age cohorts: 15-45 and >55 years of age (yoa). Unadjusted and adjusted (based on Utstein characteristics) chi square tests and logistic regression models were employed to examine the relationship between gender, age, and survival outcomes.

resultsThis study enrolled 14,690 patients: of which 36.4% were women with a mean age of 68.3 and 63.6% of them men with a mean age of 64.2. Women survived to hospital discharge less often than men (6.4% vs. 9.1%, p<0.001); the unadjusted OR was 0.69, 95%CI: 0.60, 0.77 whereas when adjusted for all Utstein predictors the difference was not significant (OR: 1.16, 95%CI: 0.98, 1.36, p=0.07). The adjusted survival rate for younger women (15-45 yoa) was 11.1% vs. 9.8% for younger men (OR: 1.66, 95%CI: 1.04, 2.64, p=0.03) but no difference in discharge rates was observed in the >55 cohort (OR: 0.94, 95%CI: 0.78, 1.15, p=0.57).

conclusionsWomen who suffer OHCAs have lower rates of survival and have unfavourable Utstein predictors. When survival is adjusted for these predictors survival is similar between men and women except in younger women suggesting that age modifies the association of gender and survival from OHCA; a result that supports a protective hormonal effect among premenopausal women.

Indexed as

AdolescentAdultAgedAged, 80 and overCardiopulmonary ResuscitationCohort StudiesEmergency Medical ServicesFemaleHumansLogistic ModelsMaleMiddle AgedNorth AmericaOut-of-Hospital Cardiac ArrestPatient DischargeSex FactorsAdult populationCardiopulmonary resuscitationGenderHeart arrestOut of hospital cardiac arrest

Identifiers

PMID26705971
PMCPMC4761304
OpenAlexW2219754188

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.