Evidence map›Paper›PMID 26705891›Full record

ArticleUltrasound in medicine & biology2016

Quest for the Vulnerable Atheroma: Carotid Stenosis and Diametric Strain--A Feasibility Study.

Canxing Xu, Chun Yuan, Edward Stutzman, Gador Canton, Keith A Comess, Kirk W Beach

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Preventing carotid stroke.Annals of translational medicine · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Canxing XuDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Chun YuanDepartment of Bioengineering, University of Washington, Seattle, Washington, USA; Department of Radiology, Vascular Imaging Laboratory, University of Washington, Seattle, Washington, USA.
Edward StutzmanD. E. Strandness, Jr. Vascular Laboratory, University of Washington Medical Center, Seattle, Washington, USA.
Gador CantonDepartment of Radiology, Vascular Imaging Laboratory, University of Washington, Seattle, Washington, USA.
Keith A ComessRetired.
Kirk W BeachDepartment of Bioengineering, University of Washington, Seattle, Washington, USA; Department of Radiology, Vascular Imaging Laboratory, University of Washington, Seattle, Washington, USA; Department of Surgery, University of Washington, Seattle, Washington, USA. Electronic address: kwbeach@usa.net.
University of Washington · USUniversity of Washington Medical Center · US

Funding

Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical SequelaeR01HL103609 · NHLBI · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS, YUAN, CHUN · 2011 to 2021
$7.1M
Atherosclerotic Plaque Neovascular InflationR21EB006825 · NIBIB · UNIVERSITY OF WASHINGTON · PI BEACH, KIRK W · 2007 to 2008
$408k
NHLBI NIH HHS R01 HL103609NIBIB NIH HHS R21 EB006825
6 · The paper itself

Abstract

The Bernoulli effect may result in eruption of a vulnerable carotid atheroma, causing a stroke. We measured electrocardiography (ECG)-registered QRS intra-stenotic blood velocity and atheroma strain dynamics in carotid artery walls using ultrasonic tissue Doppler methods, providing displacement and time resolutions of 0.1 μm and 3.7 ms. Of 22 arteries, 1 had a peak systolic velocity (PSV) >280 cm/s, 4 had PSVs between 165 and 280 cm/s and 17 had PSVs <165 cm/s. Eight arteries with PSVs <65 cm/s and 4 of 9 with PSVs between 65 and 165 cm/s had normal systolic diametric expansion (0% and 7%) and corresponding systolic wall thinning. The remaining 10 arteries had abnormal systolic strain dynamics, 2 with diametric reduction (>-0.05 mm), 2 with extreme wall expansion (>0.1 mm), 2 with extreme wall thinning (>-0.1 mm) and 4 with combinations. Decreases in systolic diameter and/or extreme systolic arterial wall thickening may indicate imminent atheroma rupture.

Indexed as

Blood Flow VelocityCardiac-Gated Imaging TechniquesCarotid StenosisElasticity Imaging TechniquesElastic ModulusFeasibility StudiesHumansImage EnhancementImage Interpretation, Computer-AssistedPerfusion ImagingPlaque, AtheroscleroticReproducibility of ResultsSensitivity and SpecificityVascular StiffnessAtheromaAtherosclerosisCarotidStrainTissue DopplerVasa plaquorumVasa vasorumVulnerable plaque

Identifiers

PMID26705891
PMCPMC4744121
OpenAlexW2197130362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.