Evidence map›Paper›PMID 26705751›Full record

ArticleJournal of cardiac failure2016

Monocyte Subsets and Inflammatory Cytokines in Acute Decompensated Heart Failure.

Sascha N Goonewardena, Adam B Stein, Ryan E Tsuchida, Rahul Rattan, Dhavan Shah, Scott L Hummel

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiac failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05916586 (Effect of Short-Term Prednisone Therapy on C-reactive Protein Change in Emergency Department Patients With Acute Heart Failure and Elevated Inflammatory Markers), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05916586 nacompletednot on this mapstarted 2023, after this paper: background citation

Effect of Short-Term Prednisone Therapy on C-reactive Protein Change in Emergency Department Patients With Acute Heart Failure and Elevated Inflammatory Markers

TypeinterventionalSponsorHeart InitiativeRan2023 to 2024Enrolled101ConditionsAcute Heart FailureArmsPrednisone
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sascha N GoonewardenaUniversity of Michigan, Ann Arbor, Michigan; Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan. Electronic address: sngoonew@med.umich.edu.
Adam B SteinUniversity of Michigan, Ann Arbor, Michigan.
Ryan E TsuchidaUniversity of Michigan, Ann Arbor, Michigan.
Rahul RattanUniversity of Michigan, Ann Arbor, Michigan.
Dhavan ShahUniversity of Michigan, Ann Arbor, Michigan.
Scott L HummelUniversity of Michigan, Ann Arbor, Michigan; Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan. Electronic address: scothumm@med.umich.edu.
University of Michigan–Ann Arbor · US

Funding

Diet and pathophysiology of heart failure with preserved ejection fractionK23HL109176 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUMMEL, SCOTT L · 2011 to 2015
$795k
Macrophage-specific nanoparticles to understand atherosclerosisK08HL123621 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOONEWARDENA, SASCHA NILU · 2015 to 2019
$783k
DASH-SRD Post Acute Decompensated Heart Failure HospitalizationR21AG047939 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUMMEL, SCOTT L, MAURER, MATHEW S · 2014 to 2015
$418k
NHLBI NIH HHS K08 HL123621NHLBI NIH HHS K23 HL109176NIA NIH HHS R21 AG047939
6 · The paper itself

Abstract

backgroundDistinct monocyte subsets predict cardiovascular risk and contribute to heart failure progression in murine models, but they have not been examined in clinical acute decompensated heart failure (ADHF). METHODS AND

resultsBlood samples were obtained from 11 healthy control subjects (HCs) and at admission and discharge from 19 ADHF patients. Serologic markers of inflammation were assessed at admission and discharge. Monocyte populations were defined with the use of flow cytometry for cell-surface expression of CD14 and CD16: CD14++CD16- (classic), CD14++CD16+ (intermediate), and CD14+CD16++ (nonclassic). In ADHF patients, C-reactive protein (CRP) and interleukin-6 (IL-6) were higher compared with HCs (both P < .001) and decreased from admission to discharge (CRP: 12.1 ± 10.1 to 8.6 ± 8.4 mg/L [P = .005]; IL-6: 19.8 ± 34.5 to 7.1 ± 4.7 pg/mL [P = .08]). In ADHF patients, the admission proportion of CD14++CD16- monocytes was lower (68% vs 85%; P < .001) and that of CD14++CD16+ (15% vs 8%; P = .002) and CD14+CD16++ (17% vs 7%, P = .07) monocytes higher compared with HCs. Additionally, the proportion of CD14++CD16- monocytes increased (68% to 79%, P = .04) and the CD14+CD16++ monocytes decreased (17% to 7%, P = .049) between admission and discharge.

conclusionsFollowing standard treatment of ADHF, the monocyte profile and circulating inflammatory markers shifts to more closely resemble those of HC, suggesting a resolution of the acute inflammatory state. Functional studies are warranted to understand how specific monocyte subsets and systemic inflammation may contribute to ADHF pathophysiology.

Indexed as

Acute DiseaseAgedBiomarkersCytokinesFemaleHeart FailureHumansInflammationMaleMiddle AgedMonocytesBiomarkersCytokinesHeart failureinflammationinnate immunitymonocytes

Identifiers

PMID26705751
PMCPMC4861694
OpenAlexW2205331386

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.