Evidence map›Paper›PMID 26705693›Full record

ReviewCurrent opinion in neurobiology2016

Modeling psychiatric disorders with patient-derived iPSCs.

Zhexing Wen, Kimberly M Christian, Hongjun Song, Guo-li Ming

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhexing WenInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kimberly M ChristianInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Hongjun SongInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Guo-li MingInstitute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: gming1@jhmi.edu.
Johns Hopkins University · US

Funding

Development of new neurons in the adult brainR01NS047344 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SONG, HONGJUN · 2003 to 2011
$3.4M
Research Center for Molecular Pathogenesis of SchizophreniaP20MH084018 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2008 to 2010
$3.3M
Circuitry mechanisms underlying normal and aberrant adult hippocampal neurogenesisR01MH105128 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2014 to 2018
$2.0M
Neural Development of Human Induced Pluripotent Stem Cells from Schizophrenia PatR33MH087874 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SONG, HONGJUN · 2011 to 2012
$805k
Neural Development of Human Induced Pluripotent Stem Cells from Schizophrenia PatR21MH087874 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SONG, HONGJUN · 2009 to 2010
$488k
Development of forebrain organoid platform for modelling human cortical neurogenesisR21NS095348 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MING, GUO-LI · 2015 to 2016
$294k
NIMH NIH HHS MH087874NIMH NIH HHS P20 MH084018NIMH NIH HHS R01 MH105128NIMH NIH HHS R21 MH087874NIMH NIH HHS R33 MH087874NINDS NIH HHS NS095348NINDS NIH HHS R01 NS047344NINDS NIH HHS R21 NS095348
6 · The paper itself

Abstract

Psychiatric disorders are heterogeneous disorders characterized by complex genetics, variable symptomatology, and anatomically distributed pathology, all of which present challenges for effective treatment. Current treatments are often blunt tools used to ameliorate the most severe symptoms, often at the risk of disrupting functional neural systems, thus there is a pressing need to develop rational therapeutics. Induced pluripotent stem cells (iPSCs) reprogrammed from patient somatic cells offer an unprecedented opportunity to recapitulate both normal and pathologic human tissue and organ development, and provides new approaches for understanding disease mechanisms and for drug discovery with higher predictability of their effects in humans. Here we review recent progress and challenges in using human iPSCs for modeling neuropsychiatric disorders and developing novel therapeutic strategies.

Indexed as

Induced Pluripotent Stem CellsAutism Spectrum DisorderAutistic DisorderBipolar DisorderChromosome DeletionChromosome DisordersChromosomes, Human, Pair 22HumansLong QT SyndromeMajor Depressive DisorderMental DisordersModels, NeurologicalRett SyndromeSchizophreniaSyndactylyWilliams Syndrome

Identifiers

PMID26705693
PMCPMC4738077
OpenAlexW2217090715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.