ArticleThe EMBO journal1989
Murine myeloid cell lines derived by in vitro infection with recombinant c-myb retroviruses express myb from rearranged vector proviruses.
Article in The EMBO journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Review
- TLX1 (HOX11) immortalization of embryonic stem cell-derived and primary murine hematopoietic progenitors.Current protocols in stem cell biology · 2008Article
- Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.Oncogene · 2006Article
- Positive and negative regulation of c-Myb by cyclin D1, cyclin-dependent kinases, and p27 Kip1.Blood · 2005Article
- Article
- Functional analysis of carboxy-terminal deletion mutants of c-Myb.Journal of virology · 1999Article
- Article
- Review
- Transformation by v-Myb.Oncogene · 1999Review
- High-efficiency identification of genes by functional analysis from a retroviral cDNA expression library.Journal of virology · 1994Article
- A simple and efficient procedure for generating stable expression libraries by cDNA cloning in a retroviral vector.Molecular and cellular biology · 1994Article
- Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo.Molecular and cellular biology · 1993Article
- New sites of proviral integration associated with murine promonocytic leukemias and evidence for alternate modes of c-myb activation.Journal of virology · 1992Article
- Expression of the CD4 gene requires a Myb transcription factor.Molecular and cellular biology · 1992Article
- Activation of the c-myb locus is insufficient for the rapid induction of disseminated avian B-cell lymphoma.Journal of virology · 1992Article
- Protein truncation is required for the activation of the c-myb proto-oncogene.Molecular and cellular biology · 1991Article
- Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro.The EMBO journal · 1989Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, cellular transformation in vitro by the myb oncogene has been described for avian haemopoietic cells only. In order to exploit the well-characterized murine haemopoietic system to study transformation by myb, we have infected fetal liver cells with retroviral vectors carrying cDNAs that encode either complete or carboxy-terminally truncated c-myb proteins. We describe four cell lines which, despite our ability to efficiently infect haemopoietic target cells, were generated at low frequency. This was due, as least in part, to the requirement for a rearrangement within the vector that allowed expression of myb sequences. Three of the lines express a truncated myb protein while the fourth apparently expresses a normal c-myb protein, and thus constitutes an exception to the general association of truncation with transformation by myb. All four cell lines resemble immature cells of the myelomonocytic lineage and are dependent on colony-stimulating factors (CSFs) for their growth in vitro. One representative line could be converted to CSF-independence by infection with either Abelson murine leukaemia virus or a recombinant granulocyte-macrophage-CSF-encoding retrovirus; unlike the parental line, the resultant sublines were highly tumorigenic when injected into syngeneic mice.
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