ArticleOpen forum infectious diseases2015
Missed Opportunities to Diagnose Tuberculosis Are Common Among Hospitalized Patients and Patients Seen in Emergency Departments.
Article in Open forum infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- An impaired T-cell-mediated mitogen response as a potential biomarker to aid in clinical diagnosis of pulmonary tuberculosis.Infection · 2026Article
- Tuberculosis Diagnostic Delays and Treatment Outcomes among Patients with COVID-19, California, USA, 2020.Emerging infectious diseases · 2024Article
- The incidence, duration, risk factors, and age-based variation of missed opportunities to diagnose pertussis: A population-based cohort study.Infection control and hospital epidemiology · 2023Article
- Optimizing measurement of misdiagnosis-related harms using symptom-disease pair analysis of diagnostic error (SPADE): comparison groups to maximize SPADE validity.Diagnosis (Berlin, Germany) · 2023Article
- A comprehensive framework to estimate the frequency, duration, and risk factors for diagnostic delays using bootstrapping-based simulation methods.BMC medical informatics and decision making · 2023Article
- Application of big data and artificial intelligence in epidemic surveillance and containment.Intelligent medicine · 2023Review
- Missed Opportunities in the Diagnosis of Tuberculosis Meningitis.Open forum infectious diseases · 2023Article
- A clinically-guided unsupervised clustering approach to recommend symptoms of disease associated with diagnostic opportunities.Diagnosis (Berlin, Germany) · 2023Article
- Molecular surveillance for large outbreaks of tuberculosis in the United States, 2014-2018.Tuberculosis (Edinburgh, Scotland) · 2022Article
- Diagnostic delays in infectious diseases.Diagnosis (Berlin, Germany) · 2022Article
- Frequency and Duration of, and Risk Factors for, Diagnostic Delays Associated with Histoplasmosis.Journal of fungi (Basel, Switzerland) · 2022Article
- Infectious diseases prevention and control using an integrated health big data system in China.BMC infectious diseases · 2022Article
- Missed Tuberculosis Investigations and Associated Factors in Patients with Symptoms Indicative of Tuberculosis at Public Health Institutions in Northwest Ethiopia: The Application of a Negative Binomial Model.Infection and drug resistance · 2022Article
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- Potential missed opportunities for diagnosis of cryptococcosis and the association with mortality: A cohort study.EClinicalMedicine · 2020Article
- Pleuropulmonary tuberculosis with spinal lesions due to metastatic malignancy differentiated definitively on imaging.BMJ case reports · 2018Article
- Internal Medicine Residents' Knowledge and Practice of Pulmonary Tuberculosis Diagnosis.Open forum infectious diseases · 2018Article
- Increasing likelihood of advanced pulmonary tuberculosis at initial diagnosis in a low-incidence US state.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018Article
- Who are the patients with tuberculosis who are diagnosed in emergency facilities? An analysis of treatment outcomes in the state of São Paulo, Brazil.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Background. Delayed diagnosis of tuberculosis (TB) may lead to worse outcomes and additional TB exposures. Methods. To estimate the potential number of misdiagnosed TB cases, we linked all hospital and emergency department (ED) visits in California's Healthcare Cost and Utilization Project (HCUP) databases (2005-2011). We defined a potential misdiagnosis as a visit with a new, primary diagnosis of TB preceded by a recent respiratory-related hospitalization or ED visit. Next, we calculated the prevalence of potential missed TB diagnoses for different time windows. We also computed odds ratios (OR) comparing the likelihood of a previous respiratory diagnosis in patients with and without a TB diagnosis, controlling for patient and hospital characteristics. Finally, we determined the correlation between a hospital's TB volume and the prevalence of potential TB misdiagnoses. Results. Within 30 days before an initial TB diagnosis, 15.9% of patients (25.7% for 90 days) had a respiratory-related hospitalization or ED visit. Also, within 30 days, prior respiratory-related visits were more common in patients with TB than other patients (OR = 3.83; P < .01), controlling for patient and hospital characteristics. Respiratory diagnosis-related visits were increasingly common until approximately 90 days before the TB diagnosis. Finally, potential misdiagnoses were more common in hospitals with fewer TB cases (ρ = -0.845; P < .01). Conclusions. Missed opportunities to diagnose TB are common and correlate inversely with the number of TB cases diagnosed at a hospital. Thus, as TB becomes infrequent, delayed diagnoses may increase, initiating outbreaks in communities and hospitals.
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