Evidence map›Paper›PMID 26705516›Full record

ArticleSchizophrenia research. Cognition2016

Neuroscience-informed Auditory Training in Schizophrenia: A Final Report of the Effects on Cognition and Serum Brain-Derived Neurotrophic Factor.

Melissa Fisher, Synthia H Mellon, Owen Wolkowitz, Sophia Vinogradov

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research. Cognition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04040829 (Cognitive Remediation and Supported Education in Psychotic Disorders), which is not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04040829 naterminatednot on this mapstarted 2021, after this paper: background citation

Cognitive Remediation and Supported Education in Psychotic Disorders: a Randomized Controlled Trial on the Efficacy and the Best Predictors of Academic Functioning

TypeinterventionalSponsorCentre de Recherche de l'Institut Universitaire en Santé Mentale de QuébecRan2021 to 2023Enrolled9ConditionsPsychotic DisordersArmsCognitive remediation therapy (CR), Supported education (SE), Treatment as usual (TAU)
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Video games for people with schizophrenia.The Cochrane database of systematic reviews · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Melissa FisherDepartment of Psychiatry, University of California, San Francisco, CA, United States ; Department of Psychiatry, San Francisco VA Medical Center, San Francisco, CA, United States.
Synthia H MellonDepartment of Obstetrics, Gynecology, Reproductive Sciences, University of California, San Francisco, United States.
Owen WolkowitzDepartment of Psychiatry, University of California, San Francisco, CA, United States.
Sophia VinogradovDepartment of Psychiatry, University of California, San Francisco, CA, United States ; Department of Psychiatry, San Francisco VA Medical Center, San Francisco, CA, United States.
University of California, San Francisco · US

Funding

Cognitive Remediation of Schizophrenia in a Community Mental Health SettingR01MH068725 · NIMH · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI VINOGRADOV, SOPHIA · 2004 to 2014
$4.9M
Brain-Plasticity Based Training for SchizophreniaR42MH073358 · NIMH · POSIT SCIENCE CORPORATION · PI MERZENICH, MICHAEL · 2005 to 2005
$140k
NIMH NIH HHS R01 MH068725NIMH NIH HHS R42 MH073358
6 · The paper itself

Abstract

objectiveWe previously reported the interim effects in a per protocol analysis of a randomized controlled trial of an innovative neuroscience-informed computerized cognitive training approach in schizophrenia. Here we report the effects of training on behavioral outcome measures in our final sample using an intent-to-treat analysis. We also report the effects on serum brain-derived neurotrophic factor (BDNF).

methodEighty-seven clinically stable participants with schizophrenia were randomly assigned to either targeted auditory training (AT, N=46) or a computer games control condition (CG, N=41). Participants were assessed on neurocognition, symptoms and functional outcome at baseline and after 50 hours of intervention delivered over 10 weeks. Serum BDNF was assessed at baseline, at 2 weeks, and at 10 weeks.

resultsAfter the intervention, AT participants showed significant gains in global cognition, speed of processing, verbal learning, and verbal memory, relative to CG participants, with no changes in symptoms or functioning. At baseline, schizophrenia participants had significantly lower-than-normal serum BDNF. AT participants showed a significant increase in serum BDNF compared to CG participants, and "normalized" levels by post training.

conclusionsParticipants with chronic schizophrenia made significant cognitive gains after 50 hours of intensive computerized training delivered as a stand-alone treatment, but no improvement in symptoms or functioning. Serum BDNF levels were significantly increased, and may serve as a peripheral biomarker for the effects of training. Future research must focus on: 1) Methods of integrating cognitive training with psychosocial treatments; 2) A deeper understanding of underlying neurophysiology in order to enhance critical mechanisms of action.

Indexed as

BDNFcognitive remediationneuroplasticitySchizophrenia

Identifiers

PMID26705516
PMCPMC4685735
OpenAlexW2188819222

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.