ArticleeLife2015
Dendritic nonlinearities are tuned for efficient spike-based computations in cortical circuits.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Flexible integration of natural stimuli by auditory cortical neurons.Journal of neurophysiology · 2026Article
- Information transfer and recovery for the sense of touch.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Conscious active inference I: A quantum model naturally implements the path integral needed for real-time planning and control.Computational and structural biotechnology journal · 2025Review
- Learning to use landmarks for navigation amplifies their representation in retrosplenial cortex.bioRxiv : the preprint server for biology · 2024Article
- Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites.Neuron · 2024Article
- Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channels.The Journal of physiology · 2023Article
- Article
- Assessing Local and Branch-specific Activity in Dendrites.Neuroscience · 2022Article
- Input rate encoding and gain control in dendrites of neocortical pyramidal neurons.Cell reports · 2022Article
- Article
- Impact of functional synapse clusters on neuronal response selectivity.Nature communications · 2020Article
- CaBiophysical journal · 2020Article
- Dendritic Spikes Expand the Range of Well Tolerated Population Noise Structures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Simple framework for constructing functional spiking recurrent neural networks.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Diverse synaptic and dendritic mechanisms of complex spike burst generation in hippocampal CA3 pyramidal cells.Nature communications · 2019Article
- Article
- The Redemption of Noise: Inference with Neural Populations.Trends in neurosciences · 2018Review
- Embedded ensemble encoding hypothesis: The role of the "Prepared" cell.Journal of neuroscience research · 2018Review
- Redundancy in synaptic connections enables neurons to learn optimally.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Cortical neurons integrate thousands of synaptic inputs in their dendrites in highly nonlinear ways. It is unknown how these dendritic nonlinearities in individual cells contribute to computations at the level of neural circuits. Here, we show that dendritic nonlinearities are critical for the efficient integration of synaptic inputs in circuits performing analog computations with spiking neurons. We developed a theory that formalizes how a neuron's dendritic nonlinearity that is optimal for integrating synaptic inputs depends on the statistics of its presynaptic activity patterns. Based on their in vivo preynaptic population statistics (firing rates, membrane potential fluctuations, and correlations due to ensemble dynamics), our theory accurately predicted the responses of two different types of cortical pyramidal cells to patterned stimulation by two-photon glutamate uncaging. These results reveal a new computational principle underlying dendritic integration in cortical neurons by suggesting a functional link between cellular and systems--level properties of cortical circuits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.