Evidence map›Paper›PMID 26705327›Full record

Trial reportRheumatology (Oxford, England)2016

Pulsed electromagnetic fields in knee osteoarthritis: a double blind, placebo-controlled, randomized clinical trial.

Gian Luca Bagnato, Giovanni Miceli, Natale Marino, Davide Sciortino, Gian Filippo Bagnato

3 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Rheumatology (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 52 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 5 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01877278 nacompletednot on this map

Wearable Pulsed Electromagnetic Fields Device in Knee Osteoarthritis Patients: a Double Blinded, Randomized Clinical Trial

TypeinterventionalSponsorUniversity of MessinaRan2013 to 2014Enrolled66ConditionsKnee OsteoarthritisArmsWearable pulsed electromagnetic fields
NCT04461470 unknown statusnot on this mapstarted 2019, after this paper: background citation

6-Month Outcomes of Pulsed Electro Resonance to Nucleotide Sources Revealing Cell Sensory Experience in Pain Relief, Stress Relief and Anti-ageing Homeostatic Restoration

Typeobservational_patient_registrySponsorhz ClinicRan2019 to 2024Enrolled5,000ConditionsPain, Stress, Ageing Signs, Immunity CompromiseArmsepigenetic longitudinal waves
NCT07198750 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of High-Intensity Pulsed Electromagnetic Field Therapy as a Bimodal Intervention for Analgesia and Strengthening in Older Adults With Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial

TypeinterventionalSponsorHospital Civil de GuadalajaraRan2025 to 2026Enrolled64ConditionsKnee Osteoarthritis, Osteoarthritis, Osteo Arthritis of the Knee, GonarthrosisArmsHI-PEMF - Knee (Chronic Pain Protocol), HI-PEMF - Quadriceps (Muscle Strengthening Protocol), Home-Based Exercise Program
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 5 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gian Luca BagnatoDivision of Rheumatology, Department of Clinical and Experimental Medicine, University of Messina, Italy gbagnato@unime.it.
Giovanni MiceliDivision of Rheumatology, Department of Clinical and Experimental Medicine, University of Messina, Italy.
Natale MarinoDivision of Rheumatology, Department of Clinical and Experimental Medicine, University of Messina, Italy.
Davide SciortinoDivision of Rheumatology, Department of Clinical and Experimental Medicine, University of Messina, Italy.
Gian Filippo BagnatoDivision of Rheumatology, Department of Clinical and Experimental Medicine, University of Messina, Italy.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis trial aimed to test the effectiveness of a wearable pulsed electromagnetic fields (PEMF) device in the management of pain in knee OA patients.

methodsIn this randomized [with equal randomization (1:1)], double-blind, placebo-controlled clinical trial, patients with radiographic evidence of knee OA and persistent pain higher than 40 mm on the visual analog scale (VAS) were recruited. The trial consisted of 12 h daily treatment for 1 month in 60 knee OA patients. The primary outcome measure was the reduction in pain intensity, assessed through VAS and WOMAC scores. Secondary outcomes included quality of life assessment through the 36-item Medical Outcomes Study Short-Form version 2 (SF-36 v2), pressure pain threshold (PPT) and changes in intake of NSAIDs/analgesics.

resultsSixty-six patients were included, and 60 completed the study. After 1 month, PEMF induced a significant reduction in VAS pain and WOMAC scores compared with placebo. Additionally, pain tolerance, as expressed by PPT changes, and physical health improved in PEMF-treated patients. A mean treatment effect of -0.73 (95% CI - 1.24 to - 0.19) was seen in VAS score, while the effect size was -0.34 (95% CI - 0.85 to 0.17) for WOMAC score. Twenty-six per cent of patients in the PEMF group stopped NSAID/analgesic therapy. No adverse events were detected.

conclusionThese results suggest that PEMF therapy is effective for pain management in knee OA patients and also affects pain threshold and physical functioning. Future larger studies, including head-to-head studies comparing PEMF therapy with standard pharmacological approaches in OA, are warranted.

trial registrationClinicalTrials.gov, http://www.clinicaltrials.gov, NCT01877278.

Indexed as

AgedAged, 80 and overAnalgesicsAnti-Inflammatory Agents, Non-SteroidalDouble-Blind MethodDrug Administration ScheduleFemaleHumansMagnetic Field TherapyMaleMiddle AgedOsteoarthritis, KneePain ManagementPain MeasurementPain ThresholdAnalgesicsAnti-Inflammatory Agents, Non-Steroidalclinical trialkneeOApainpain threshold

Identifiers

PMID26705327
PMCPMC4795538
OpenAlexW2253533627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.