Observational studyMedicine2015
Depression and the Risk of Peptic Ulcer Disease: A Nationwide Population-Based Study.
Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Dissecting pleiotropy between major depressive disorder and physical disease comorbidities.Nature genetics · 2026Article
- Article
- Factor Structures in the Depressive Symptoms Domains in the 9Q for Northern Thai Adults and Their Association with Chronic Diseases.Behavioral sciences (Basel, Switzerland) · 2024Article
- Immune function, gastrointestinal hormone levels, and their clinical significance in patients with gastric ulcers complicated with depression.World journal of psychiatry · 2023Article
- Exploring the relationship between distress rumination, resilience, depression, and self-injurious behaviors among Chinese college athletes infected with COVID-19: a cross-sectional study.Frontiers in psychiatry · 2023Article
- Article
- Sex Differences in Comorbidity Combinations in the Swedish Population.Biomolecules · 2022Article
- Polypharmacy in elderly people.Wiener medizinische Wochenschrift (1946) · 2022Review
- GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression.Nature communications · 2021Article
- Beneficial Effect of Alkaloids FromFrontiers in cellular and infection microbiology · 2021Article
- Peptic ulcer does not increase the risk of dementia: A nested case control study using a national sample cohort.Medicine · 2020Observational
- Reciprocal association between depression and peptic ulcers: Two longitudinal follow-up studies using a national sample cohort.Scientific reports · 2020Article
- Safety and Effectiveness of Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation and Anemia: A Retrospective Cohort Study.Journal of the American Heart Association · 2019Article
- Insect tea attenuates hydrochloric acid and ethanol-induced mice acute gastric injury.Experimental and therapeutic medicine · 2017Article
- [Duodenal ulcers, gastric ulcers and Helicobacter pylori].Zeitschrift fur Gerontologie und Geriatrie · 2017Review
- Statin Therapy Is Associated with Reduced Risk of Peptic Ulcer Disease in the Taiwanese Population.Frontiers in pharmacology · 2017Article
- Article
- Bidirectional association between obstructive sleep apnea and depression: A population-based longitudinal study.Medicine · 2016Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk of peptic ulcer disease (PUD) among patients with depression has raised concern. This study determined the association between depression and the subsequent development of PUD using claims data.Patients newly diagnosed with depression in 2000 to 2010 were identified as depression cohort from the Taiwan National Health Insurance Research Database. The comparison cohort was randomly selected from subjects without depression, frequency matched by age and gender and diagnosis date, with a size 2-fold of the size of the depression cohort. The incidence of PUD was evaluated for both cohorts by the end of 2011. We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of PUD using the Cox proportional hazards regression model.The depression cohort consisted of 23,536 subjects (129,751 person-years), and the comparison cohort consisted of 47,069 subjects (285,592 person-years). The incidence of PUD was 2-fold higher in the depression cohort than in the comparison cohort (33.2 vs 16.8 per 1000 person-years) with an age adjusted HR of 1.97 (95% CI = 1.89-2.06) or a multivariable adjusted HR of 1.35 (95% CI = 1.29-1.42).Depression might increase the risk of developing PUD. Prospective clinical studies of the relationship between depression and PUD are warranted.
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