Evidence map›Paper›PMID 26705202›Full record

Observational studyMedicine2015

An Independent Risk of Gout on the Development of Deep Vein Thrombosis and Pulmonary Embolism: A Nationwide, Population-Based Cohort Study.

Chien-Chung Huang, Po-Hao Huang, Jiunn-Horng Chen, Joung-Liang Lan, Gregory J Tsay, Hsiao-Yi Lin, Chun-Hung Tseng, Cheng-Li Lin, Chung-Yi Hsu

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Uric Acid-An Emergent Risk Marker for Thrombosis?Journal of clinical medicine · 2021
    Review
  10. Bone Marrow Gouty Tophi With Plasma Cell Myeloma.Annals of laboratory medicine · 2020
    Article
  11. Review
  12. Article
  13. Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chien-Chung HuangFrom the Division of Immunology and Rheumatology, Department of Internal Medicine (C-CH, P-HH, J-HC, J-LL, GJT), Department of Neurology (C-HT), and Management Office for Health Data (C-LL, C-YH), China Medical University Hospital, Taichung, Taiwan; School of Medicine (J-HC, J-LL, GJT, C-HT), Rheumatology Research Laboratory (C-CH, P-HH, J-HC, J-LL, GJT), Graduate Institute of Clinical Medical Science (C-YH), China Medical University, Taichung, Taiwan; Division of Immunology and Rheumatology, Department of Internal Medicine, Veterans General Hospital, Taichung, Taiwan (H-YL); and School of Medicine, National Yang-Ming Medical University, Taipei, Taiwan (H-YL).
Po-Hao Huang
Jiunn-Horng Chen
Joung-Liang Lan
Gregory J Tsay
Hsiao-Yi Lin
Chun-Hung Tseng
Cheng-Li Lin
Chung-Yi Hsu
National Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies indicated that gout is a risk factor of cardiovascular diseases. This study aimed to determine if patients with gout have an increased risk of deep vein thrombosis (DVT) or pulmonary embolism (PE).We used the Longitudinal Health Insurance Database, a subset of the national insurance claim dataset, which enrolled 1 million Taiwanese to identify 57,981 patients with gout and 115,961 reference subjects matched by sex, age, and entry date of diagnosis. The risk of DVT and PE was analyzed using the Cox proportional hazards model.In this Taiwanese dataset observed from 2000 to 2010, we found the incidence of DVT was 5.26 per 10 person-years in the gout cohort, which was twofold higher than the incidence of 2.63 per 10 person-years in the reference cohort. After adjusting for age, sex, and 9 comorbidities, the hazard ratio (HR) of developing DVT was 1.66 (95% confidence interval [CI] = 1.37-2.01). Among patients with gout, the youngest age group had the highest increase in the risk of developing DVT (HR [95% CI] = 2.04 [1.24-3.37] for ages 20 to 49 years, 1.80 [1.28-2.51] for ages 50 to 64 years, and 1.45 [1.11-1.91] for ages ≥65 years). The incidence of PE was about one-fifth that of DVT in gout patients, but the effect of gout on the risk was similar (HR [95% CI] = 1.53 [1.01-2.29]).Our analysis confirmed that gout increased the risk of DVT and PE. Further exploration is needed in the future.

Indexed as

AdultAgedAge DistributionCohort StudiesComorbidityFemaleGoutHumansIncidenceMaleMiddle AgedProportional Hazards ModelsPulmonary EmbolismRisk FactorsSex DistributionTaiwan

Identifiers

PMID26705202
PMCPMC4697968
OpenAlexW2314338891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.