Evidence map›Paper›PMID 26705159›Full record

ReviewDevelopmental and comparative immunology2016

Amphibian macrophage development and antiviral defenses.

Leon Grayfer, Jacques Robert

Open access · greenAbstract readReview
In one paragraph

Review in Developmental and comparative immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

  1. Current issues in molecular biology · 2026
    Review
  2. A perspective into the relationships between amphibian (Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Amphibian (Frontiers in immunology · 2021
    Article
  8. Review
  9. Article
  10. From Species to Regional and Local Specialization of Intestinal Macrophages.Frontiers in cell and developmental biology · 2020
    Review
  11. Cells · 2019
    Review
  12. Review
  13. Myelopoiesis of the AmphibianFrontiers in immunology · 2019
    Article
  14. Amphibian (Viruses · 2018
    Article
  15. Differentiation-dependent antiviral capacities of amphibian (The Journal of biological chemistry · 2018
    Article
  16. Article
  17. Article
  18. Evolutionary Aspects of Macrophages Polarization.Results and problems in cell differentiation · 2017
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Leon GrayferDepartment of Biological Sciences, George Washington University, Washington, DC, USA.
Jacques RobertDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: Jacques_Robert@urmc.rochester.edu.
George Washington University · USUniversity of Rochester Medical Center · US

Funding

A Xenopus Laevis Research Resource for ImmunologyR24AI059830 · NIAID · UNIVERSITY OF ROCHESTER · PI JACQUES Robert · 2004 to 2026
$7.7M
NIAID NIH HHS R24 AI059830
6 · The paper itself

Abstract

Macrophage lineage cells represent the cornerstone of vertebrate physiology and immune defenses. In turn, comparative studies using non-mammalian animal models have revealed that evolutionarily distinct species have adopted diverse molecular and physiological strategies for controlling macrophage development and functions. Notably, amphibian species present a rich array of physiological and environmental adaptations, not to mention the peculiarity of metamorphosis from larval to adult stages of development, involving drastic transformation and differentiation of multiple new tissues. Thus it is not surprising that different amphibian species and their respective tadpole and adult stages have adopted unique hematopoietic strategies. Accordingly and in order to establish a more comprehensive view of these processes, here we review the hematopoietic and monopoietic strategies observed across amphibians, describe the present understanding of the molecular mechanisms driving amphibian, an in particular Xenopus laevis macrophage development and functional polarization, and discuss the roles of macrophage-lineage cells during ranavirus infections.

Indexed as

Amphibian ProteinsAmphibiansAnimalsHematopoiesisImmunity, InnateInterleukinsLarvaMacrophagesRanavirusVirus DiseasesAmphibian ProteinsInterleukinsAmphibianColony-stimulating factor-1Interleukin-34MacrophagesMonopoiesisMyelopoiesisRanavirus

Identifiers

PMID26705159
PMCPMC4775336
OpenAlexW2217107363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.