ArticleInternational journal of pharmaceutics2016
A reproducible accelerated in vitro release testing method for PLGA microspheres.
Article in International journal of pharmaceutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Dynamic versus Static In Vitro Drug Release Testing of Subcutaneous Implants with Distinct Microstructures.ACS omega · 2026Article
- An Overview of In Vitro Release Methods for Long-Acting Injectable Products Based on PLGA.Methods and protocols · 2026Review
- Exploring New Horizons in Wound Healing: A Comprehensive Analysis.Recent advances in inflammation & allergy drug discovery · 2026Review
- Sustained-Release Intra-Articular Drug Delivery: PLGA Systems in Clinical Context and Evolving Strategies.Pharmaceutics · 2025Review
- PLGA-based long-acting injectable (LAI) formulations.Journal of controlled release : official journal of the Controlled Release Society · 2025Review
- Unveiling the Future: Opportunities in Long-Acting Injectable Drug Development for Veterinary Care.Pharmaceutics · 2025Review
- Scanning Analysis of Sequential Semisolvent Vapor Impact To Study Naltrexone Release from Poly(lactide-co-glycolide) Microparticles.Molecular pharmaceutics · 2022Article
- A review of current advancements for wound healing: Biomaterial applications and medical devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Review
- Challenges and Complications of Poly(lactic-Pharmaceutics · 2022Review
- In vitro dissolution considerations associated with nano drug delivery systems.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Recent Progress in Drug Release Testing Methods of Biopolymeric Particulate System.Pharmaceutics · 2021Review
- PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery.International journal of molecular sciences · 2021Review
- Coupling the in vivo performance to the in vitro characterization of PLGA microparticles.International journal of pharmaceutics · 2021Article
- FDA's Poly (Lactic-Co-Glycolic Acid) Research Program and Regulatory Outcomes.The AAPS journal · 2021Review
- Key Factor Study for Generic Long-Acting PLGA Microspheres Based on a Reverse Engineering of VivitrolMolecules (Basel, Switzerland) · 2021Article
- Formulation composition, manufacturing process, and characterization of poly(lactide-co-glycolide) microparticles.Journal of controlled release : official journal of the Controlled Release Society · 2021Review
- A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres.Asian journal of pharmaceutical sciences · 2019Article
- [Effect of bone morphogenetic protein 7/poly (lactide-co-glycolide) microspheres on theZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Article
- Characterization, Stability and Biological Activity In Vitro of Cathelicidin-BF-30 Loaded 4-Arm Star-Shaped PEG-PLGA Microspheres.Molecules (Basel, Switzerland) · 2018Article
- Effect of Drug Carrier Melting Points on Drug Release of Dexamethasone-Loaded Microspheres.Tissue engineering and regenerative medicine · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The objective of the present study was to develop a discriminatory and reproducible accelerated in vitro release method for long-acting PLGA microspheres with inner structure/porosity differences. Risperidone was chosen as a model drug. Qualitatively and quantitatively equivalent PLGA microspheres with different inner structure/porosity were obtained using different manufacturing processes. Physicochemical properties as well as degradation profiles of the prepared microspheres were investigated. Furthermore, in vitro release testing of the prepared risperidone microspheres was performed using the most common in vitro release methods (i.e., sample-and-separate and flow through) for this type of product. The obtained compositionally equivalent risperidone microspheres had similar drug loading but different inner structure/porosity. When microsphere particle size appeared similar, porous risperidone microspheres showed faster microsphere degradation and drug release compared with less porous microspheres. Both in vitro release methods investigated were able to differentiate risperidone microsphere formulations with differences in porosity under real-time (37 °C) and accelerated (45 °C) testing conditions. Notably, only the accelerated USP apparatus 4 method showed good reproducibility for highly porous risperidone microspheres. These results indicated that the accelerated USP apparatus 4 method is an appropriate fast quality control tool for long-acting PLGA microspheres (even with porous structures).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.