ArticleBMC oral health2015
Comparative analysis of blood and saliva expression profiles in chronic and refractory periodontitis patients.
Article in BMC oral health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Unique miRomics Expression Profiles inInternational journal of molecular sciences · 2023Article
- Transcriptomic profiles and their correlations in saliva and gingival tissue biopsy samples from periodontitis and healthy patients.Journal of periodontal & implant science · 2020Article
- Development of an miRNA-Array-Based Diagnostic Signature for Periodontitis.Frontiers in genetics · 2020Article
- Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to identify characteristic representative genes through a comparative analysis of gene expression profiles in the blood and saliva of chronic periodontitis (CP) and refractory periodontitis (RP) patients to provide new treatment strategies that may be helpful in the treatment of different forms of periodontitis.
methodsGSE43525 was downloaded from Gene Expression Omnibus. In the dataset, thirteen samples were from blood including 4 controls, 4 CP and 5 RP samples, and ten samples were from saliva including 3 controls, 4 CP and 3 RP samples. After comparing the CP and RP samples, differentially expressed genes (DEGs) between these two types of periodontitis in the blood and saliva samples were identified by an LIMMA package. Then, functional and pathway enrichment analyses were performed by DAVID and KOBAS, respectively. The significantly associated miRNAs in CP and RP were searched by WebGestalt.
resultsIn total, 213 DEGs in CP and 45 DEGs in RP were identified. Functional enrichment showed that the DEGs of CP were mainly enriched in ribosome and regulation of apoptosis-related pathways in blood as well as saliva, while the DEGs of RP were significantly enriched in immune responses and response to organic substance-related pathways. Several miRNAs, such as miR-381 and miR-494, were identified as being closely associated with CP. In addition, CD24, EST1, MTSS1, ING3, CCND2 and SYNE2 might be potential targets for diagnosis and treatment of CP.
conclusionThe identified DEGs and miRNAs might be potential targets for the treatment of chronic and refractory periodontitis.
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