ArticleInternational journal of cancer2016
Trajectory of body shape across the lifespan and cancer risk.
Article in International journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 6 of them syntheses that pooled it.
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Who cites it
89 citing papers in PubMed, 6 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Life Course Trajectories of Body Mass Index and Risk of Cancer in Adulthood: Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Lifecourse genome-wide association study meta-analysis refines the critical life stages for adiposity's influence on breast cancer risk.Science advances · 2026Pooled it
- Early-life anthropometry and colorectal cancer risk in adulthood: Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis of prospective studies.International journal of cancer · 2025Pooled it
- Body Composition and Prostate Cancer Risk: A Systematic Review of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Association between weight cycling and risk of kidney cancer: a prospective cohort study and meta-analysis of observational studies.Cancer causes & control : CCC · 2021Pooled it
- Abdominal obesity and gastroesophageal cancer risk: systematic review and meta-analysis of prospective studies.Bioscience reports · 2017Pooled it
- Prediagnostic Body Mass Index Trajectories in Relation to Prostate Cancer Incidence and Mortality in the PLCO Cancer Screening Trial.Journal of the National Cancer Institute · 2017Trial
- Weight trajectories throughout adulthood and prostate cancer incidence, aggressiveness, and death in 258 494 men.Journal of the National Cancer Institute · 2026Article
- Individual and environmental determinants of body mass index trajectories: results from a longitudinal study in Southern Sweden.BMC public health · 2026Article
- Pre-diagnostic body mass index trajectories and associations with lung cancer risk.American journal of epidemiology · 2026Article
- Adolescent to adulthood weight trajectories and the risk of obesity-related cancers, overall and early-onset: a population-based cohort study.EClinicalMedicine · 2026Article
- Association of childhood-to-adulthood body size change with cancer risk: UK Biobank prospective cohort.BMC medicine · 2025Article
- Timing of depression in relation to risk of ovarian cancer.Journal of the National Cancer Institute · 2025Article
- High-Fat Diet and Altered Radiation Response.Biology · 2025Review
- Body mass index across adulthood, weight gain and cancer risk: a population-based cohort study.BMC cancer · 2025Article
- Body shape phenotype, TYG trajectory and the risk of digestive system cancers.Frontiers in nutrition · 2025Article
- From Surviving to Thriving: Key Considerations for Weight Control Across Diverse Cancer Survivorship Populations.Obesity science & practice · 2024Review
- Adiposity assessed close to diagnosis and prostate cancer prognosis in the EPIC study.JNCI cancer spectrum · 2024Article
- Excess weight, weight gain, and prostate cancer risk and prognosis: the PROCA-life study.Acta oncologica (Stockholm, Sweden) · 2024Article
- A longitudinal investigation of risk perceptions and adaptation behavior in the US Gulf Coast.PNAS nexus · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The influence of adiposity over life course on cancer risk remains poorly understood. We assessed trajectories of body shape from age 5 up to 60 using a group-based modeling approach among 73,581 women from the Nurses' Health Study and 32,632 men from the Health Professionals Follow-up Study. After a median of approximately 10 years of follow-up, we compared incidence of total and obesity-related cancers (cancers of the esophagus [adenocarcinoma only], colorectum, pancreas, breast [after menopause], endometrium, ovaries, prostate [advanced only], kidney, liver and gallbladder) between these trajectories. We identified five distinct trajectories of body shape: lean-stable, lean-moderate increase, lean-marked increase, medium-stable, and heavy-stable/increase. Compared with women in the lean-stable trajectory, those in the lean-marked increase and heavy-stable/increase trajectories had a higher cancer risk in the colorectum, esophagus, pancreas, kidney, and endometrium (relative risk [RR] ranged from 1.22 to 2.56). Early life adiposity was inversely while late life adiposity was positively associated with postmenopausal breast cancer risk. In men, increased body fatness at any life period was associated with a higher risk of esophageal adenocarcinoma and colorectal cancer (RR ranged from 1.23 to 3.01), and the heavy-stable/increase trajectory was associated with a higher risk of pancreatic cancer, but lower risk of advanced prostate cancer. The trajectory-cancer associations were generally stronger for non-smokers and women who did not use menopausal hormone therapy. In conclusion, trajectories of body shape throughout life were related to cancer risk with varied patterns by sex and organ, indicating a role for lifetime adiposity in carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.