ArticleNeurorehabilitation and neural repair2016
Effects of Subdural Monopolar Cortical Stimulation Paired With Rehabilitative Training on Behavioral and Neurophysiological Recovery After Cortical Ischemic Stroke in Adult Squirrel Monkeys.
Article in Neurorehabilitation and neural repair, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Is there a correlation between functional recovery of manual dexterity after motor cortex lesion and initial motor learning slope in the intact state?Frontiers in systems neuroscience · 2026Article
- Re-Examination and Extension of Manual Dexterity Behavioral Data in M1 Lesioned Adult Macaque Monkeys: A Survey of Therapies Induced Enhancement of Functional Recovery.Neuroscience insights · 2026Article
- Confirmation of the Enhancement Effect of ANCE Treatment on Functional Recovery of Manual Dexterity From Primary Motor Cortex (M1) Lesion in Adult Macaque Monkeys.Brain and behavior · 2025Article
- Non-human primate models of focal cortical ischemia for neuronal replacement therapy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- Spared Premotor Areas Undergo Rapid Nonlinear Changes in Functional Organization Following a Focal Ischemic Infarct in Primary Motor Cortex of Squirrel Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Rehabilitation combined with neural progenitor cell grafts enables functional recovery in chronic spinal cord injury.JCI insight · 2022Article
- Reorganization of Ventral Premotor Cortex After Ischemic Brain Injury: Effects of Forced Use.Neurorehabilitation and neural repair · 2022Article
- A cortical injury model in a non-human primate to assess execution of reach and grasp actions: implications for recovery after traumatic brain injury.Journal of neuroscience methods · 2021Article
- Comparative Enhancement of Motor Function and BDNF Expression Following Different Brain Stimulation Approaches in an Animal Model of Ischemic Stroke.Neurorehabilitation and neural repair · 2020Article
- Cerebellar Neuromodulation for Stroke.Current physical medicine and rehabilitation reports · 2020Article
- Regenerative Rehabilitation for Stroke Recovery by Inducing Synergistic Effects of Cell Therapy and Neurorehabilitation on Motor Function: A Narrative Review of Pre-Clinical Studies.International journal of molecular sciences · 2020Review
- Article
- Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke.Nature medicine · 2018Article
- Understanding the Mechanisms of Recovery and/or Compensation following Injury.Neural plasticity · 2017Review
- Novel Neuromodulation Techniques to Assess Interhemispheric Communication in Neural Injury and Neurodegenerative Diseases.Frontiers in neural circuits · 2017Review
- Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey.Restorative neurology and neuroscience · 2016Article
- Effects of motor cortex neuromodulation on the specificity of corticospinal tract spinal axon outgrowth and targeting in rats.Brain stimulationArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundCortical stimulation (CS) combined with rehabilitative training (RT) has proven effective for enhancing poststroke functional recovery in rats, but human clinical trials have had mixed outcomes.
objectiveTo assess the efficacy of CS/RT versus RT in a nonhuman primate model of cortical ischemic stroke.
methodsSquirrel monkeys learned a pellet retrieval task, then received an infarct to the distal forelimb (DFL) representation of primary motor cortex. A subdural monopolar electrode was implanted over the spared DFL representation in dorsal premotor cortex (PMD). Seven weeks postinfarct, monkeys underwent 4 to 6 weeks of RT (n = 8) or CS/RT (n = 7; 100 Hz, cathodal current) therapy. Behavioral performance was assessed before and after infarct, prior to therapy, and 1 and 12 weeks posttherapy (follow-up). The primary outcome measure was motor performance at 1 week posttherapy. Secondary outcomes included follow-up performance at 12 weeks and treatment-related changes in neurophysiological maps of spared DFL representations.
resultsWhile postinfarct performance deficits were found in all monkeys, both groups demonstrated similar recovery profiles, with no difference in motor recovery between the RT and CS/RT groups. Posttherapy, PMD DFL area was significantly expanded in the RT group but not the CS/RT group. A significant relationship was found between motor recovery and DFL expansion in premotor cortex.
conclusionsResults suggest that the specific parameters utilized here were not optimal for promoting behavioral recovery in nonhuman primates. Though CS/RT has consistently shown efficacy in rat stroke models, the present finding has cautionary implications for translation of CS/RT therapy to clinical populations.
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