SynthesisEye & contact lens2016
The Safety of Orthokeratology--A Systematic Review.
Synthesis in Eye & contact lens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 10 syntheses or guidelines pooled it, 200 citations in OpenAlex.
- Duration-Dependent Efficacy and Clinical Safety of Repeated Low-Level Red-Light Therapy for Paediatric Myopia: A Systematic Review and Meta-Analysis.Clinical & experimental ophthalmology · 2026Pooled it
- Which is better for myopia control in children: orthokeratology or DIMS spectacle lenses? A meta-analysis.BMC ophthalmology · 2026Pooled it
- Efficacy comparison of atropine, orthokeratology and repeated low-level red-light therapy for myopia control in children: a systematic review and network meta-analysis.The British journal of ophthalmology · 2025Pooled it
- Guidelines for preventing and slowing myopia progression in Brazilian children.Arquivos brasileiros de oftalmologia · 2024Guideline
- The efficacy and safety of 0.01% atropine alone or combined with orthokeratology for children with myopia: A meta-analysis.PloS one · 2023Pooled it
- Myopia Control With Multifocal Lens in School-Aged Children: A Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Orthokeratology lens-relatedThe Journal of international medical research · 2021Pooled it
- Changes in axial length after orthokeratology lens treatment for myopia: a meta-analysis.International ophthalmology · 2020Pooled it
- Efficacy and safety of interventions to control myopia progression in children: an overview of systematic reviews and meta-analyses.BMC ophthalmology · 2019Pooled it
- A Review of Current Concepts of the Etiology and Treatment of Myopia.Eye & contact lens · 2018Pooled it
- Accommodation response and spherical aberration during orthokeratology.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Trial
- Compliance with orthokeratology lens wear: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Comparative effectiveness of orthokeratology versus highly aspherical lenslets in slowing myopia progression: a retrospective study.Eye and vision (London, England) · 2026Article
- Effect of Switching Myopia Control Strategies on Axial Elongation in Children with Poor Response to Highly Aspherical Lenslet Therapy.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Clinical Safety and Performance of Ultra-High Dk Tisilfocon A Orthokeratology Lenses: A Prospective Multicenter Study.Life (Basel, Switzerland) · 2026Article
- The Association of Treatment Zone Decentration With Axial Length Elongation During 2 Years of Orthokeratology Treatment.Eye & contact lens · 2026Article
- Age-Specific Efficacy of MiSight Dual-Focus Soft Contact Lenses and Orthokeratology Lenses for Myopia Control in Pediatric Patients: A Retrospective Comparative Study.Eye & contact lens · 2026Article
- Management of myopia: a mini-review.Medical hypothesis, discovery & innovation ophthalmology journal · 2026Review
- Age-indexed cumulative risk of high myopia estimated from axial length and early axial elongation: a 7-year school-based longitudinal cohort study.Frontiers in medicine · 2026Article
- Current status of school vision screening-rationale, models, impact and challenges: a review.The British journal of ophthalmology · 2025Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this review is to evaluate the ocular safety of orthokeratology (OrthoK) treatment of myopia correction and retardation. DATA SOURCES: Clinical studies published in English and Chinese were identified from MEDLINE, EMBASE CNKI, CQVIP, and WANFANG DATA (all from 1980 to April 2015). The reference lists of the studies and the Science Citation Index were also searched. SELECTION CRITERIA: Relevant clinical studies including case series, case reports, patient/practitioner surveys, retrospective and prospective cohort studies, and clinical trials were all included in the review. The material of OrthoK lenses was limited to gas-permeable lens. MAIN
resultsThis review incorporated a total of 170 publications, including 58 English and 112 Chinese literature. The risk of microbial keratitis in overnight OrthoK was similar to that of other overnight modality. The most common complication was corneal staining. Other clinically insignificant side effects included epithelial iron deposit, prominent fribrillary lines, and transient changes of corneal biomechanical properties. There was no long-term effect of OrthoK on corneal endothelium.
conclusionsThere is sufficient evidence to suggest that OrthoK is a safe option for myopia correction and retardation. Long-term success of OrthoK treatment requires a combination of proper lens fitting, rigorous compliance to lens care regimen, good adherence to routine follow-ups, and timely treatment of complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.