ArticleBehavioral and brain functions : BBF2015
Feasibility of focal cerebral ischemia and reperfusion surgery combined with chronic unpredictable mild stress to simulate the post-stroke depressive state in rats.
Article in Behavioral and brain functions : BBF, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Transcriptional profiling reveals brain region-specific changes in gene expression induced by chronic unpredictable mild stress between stress-susceptible and stress-resilient mice.Psychopharmacology · 2026Article
- Mechanism of Treadmill Exercise Combined with Rich Environmental Stimulation to Improve Depression in Post-stroke Depression Model Rats.Actas espanolas de psiquiatria · 2024Article
- Advancing Post-Stroke Depression Research: Insights from Murine Models and Behavioral Analyses.Life (Basel, Switzerland) · 2024Review
- Effects of Aloe-Emodin on the Expression of Brain Aquaporins and Secretion of Neurotrophic Factors in a Rat Model of Post-Stroke Depression.International journal of molecular sciences · 2023Article
- Recent Studies on the Development of Nicotine Abuse and Behavioral Changes Induced by Chronic Stress Depending on Gender.Brain sciences · 2023Review
- Alteration of Gut Microbiome and Correlated Lipid Metabolism in Post-Stroke Depression.Frontiers in cellular and infection microbiology · 2021Article
- Optimizing functional outcome endpoints for stroke recovery studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Review
- Improving Activity ofIranian journal of pharmaceutical research : IJPR · 2019Article
- Erratum to: Feasibility of focal cerebral ischemia and reperfusion surgery combined with chronic unpredictable mild stress to simulate the post-stroke depressive state in rats.Behavioral and brain functions : BBF · 2016Article
Corrections and comments
- Erratum issuedErratum to: Feasibility of focal cerebral ischemia and reperfusion surgery combined with chronic unpredictable mild stress to simulate the post-stroke depressive state in rats.2016 · Jin, LiXinhao [corrected to Jin, Xinhao]
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the feasibility of focal cerebral ischemia and reperfusion (FCIR) surgery combined chronic unpredictable mild stress (CUMS) to simulate the post-stroke depression (PSD) state in rats.
methodsSprague-Dawley male rats were divided randomly into five groups: the normal, sham, FCIR, CUMS, and FCIR + CUMS (F/C) groups. Rats in the FCIR and F/C groups underwent an FCIR operation. Rats in CUMS and F/C groups were single-housed and exposed to CUMS for 4 weeks. Rats in the F/C group underwent CUMS for 4 weeks after FCIR surgery. The gain in bodyweight, the sugar consumption ratio in a sucrose preference test (SPT), and behavior, including spontaneous moves (SM), the duration of time spent in the center arena (duration), and the number of rearings (rearing) in an open field test (OFT), were evaluated.
resultsRats in the CUMS and F/C groups had a smaller gain in bodyweight (P < 0.05). The sugar consumption ratio was reduced significantly in the CUMS and F/C groups compared with the normal and FCIR groups (P < 0.05). The number of SM was significantly lower in the FCIR group compared with the normal group. SM, duration, and rearing were reduced significantly in the CUMS and F/C groups relative to the normal group. Furthermore, the number of rearings was lower in the F/C group compared with the CUMS group.
conclusionAnhedonia, a lack of curiosity, and inactivity were observed in the F/C rats, which exhibited depression-like symptoms after FCIR surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.