Evidence map›Paper›PMID 26703910›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2016

Irritability and Severity of Anxious Symptomatology Among Youth With Anxiety Disorders.

Danielle Cornacchio, Kathleen I Crum, Stefany Coxe, Donna B Pincus, Jonathan S Comer

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 83 citations in OpenAlex.

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  10. Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024
    Review
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  16. Context-dependent amygdala-prefrontal connectivity during the dot-probe task varies by irritability and attention bias to angry faces.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Danielle CornacchioMental Health Interventions and Technology (MINT) Program, Center for Children and Families, Florida International University, Miami.
Kathleen I CrumMental Health Interventions and Technology (MINT) Program, Center for Children and Families, Florida International University, Miami.
Stefany CoxeMental Health Interventions and Technology (MINT) Program, Center for Children and Families, Florida International University, Miami.
Donna B PincusCenter for Anxiety and Related Disorders (CARD), Boston University, Boston.
Jonathan S ComerMental Health Interventions and Technology (MINT) Program, Center for Children and Families, Florida International University, Miami. Electronic address: jocomer@fiu.edu.
Center for Children · USBoston University · USFlorida Department of Children and Families · US

Funding

Intensive Treatment of Adolescent Panic and AgoraphobiaR01MH068277 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PINCUS, DONNA B. · 2005 to 2009
$1.8M
Evaluating the Feasibility of Internet-Delivered Parent-Child Interaction TherapyK23MH090247 · NIMH · FLORIDA INTERNATIONAL UNIVERSITY · PI COMER, JONATHAN S · 2011 to 2015
$808k
NIMH NIH HHS K23 MH090247NIMH NIH HHS K23MH090247NIMH NIH HHS R01 MH068277
6 · The paper itself

Abstract

objectiveMost research on irritability and child psychopathology has focused on depressive disorders, bipolar disorder, and/or oppositional defiant disorder (ODD). Less is known about relationships between child anxiety and irritability and moderators of such associations.

methodStructural equation modeling (SEM) was used to examine associations between anxiety severity and irritability in a large sample of treatment-seeking youth with anxiety disorders (N = 663, aged 7-19 years, mean = 12.25 years), after accounting for comorbid depressive disorders and ODD. Additional analyses examined whether associations were moderated by child gender, age, and generalized anxiety disorder (GAD) status.

resultsThere was a direct link between child anxiety and irritability even after accounting for comorbid depressive disorders and ODD. Links between child anxiety and irritability were robust across child gender and age. Furthermore, relationships between child anxiety and irritability were comparable across youth with and without GAD, suggesting that the anxiety-irritability link is relevant across child anxiety disorders and not confined to youth with GAD.

conclusionFindings add to an increasing body of evidence linking child irritability to a range of internalizing and externalizing psychopathologies, and suggest that child anxiety assessment should systematically incorporate irritability evaluations. Moreover, youth in clinical settings displaying irritability should be assessed for the presence of anxiety. Treatments for childhood anxiety may do well to incorporate new treatment modules as needed that specifically target problems of irritability.

Indexed as

Irritable MoodAdolescentAnxietyAnxiety DisordersChildComorbidityFemaleHumansMaleNew EnglandSeverity of Illness IndexSocioeconomic Factorsanxietychildirritabilitystructural equation modelingtantrums

Identifiers

PMID26703910
PMCPMC5340317
OpenAlexW1887011773

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.