Evidence map›Paper›PMID 26703875›Full record

ArticleThe Journal of pediatrics2016

Enteral Feeding with Human Milk Decreases Time to Discharge in Infants following Gastroschisis Repair.

Brian C Gulack, Matthew M Laughon, Reese H Clark, Terrance Burgess, Sybil Robinson, Abdurrauf Muhammad, Angela Zhang, Adrienne Davis, Robert Morton, Vivian H Chu and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03393832 (Oral Care), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03393832 active not recruitingnot on this mapstarted 2017, after this paper: background citation

Oral Care: An Important Adjunctive Therapy to Improve Feeding Tolerance in Infants With Gastroschisis

TypeobservationalSponsorBaylor College of MedicineRan2017 to 2026Enrolled27ConditionsGastroschisis
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Importance of human milk for infants in the clinical setting: Updates and mechanistic links.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2023
    Review
  4. Article
  5. Early pumping frequency and coming to volume for mother's own milk feeding in hospitalized infants.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Article
  6. Article
  7. Macronutrients Management for Growth in Neonates with Congenital Gastrointestinal Malformation.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Article
  8. Prevalence and patterns of gestational parent's own milk feeds among infants with major congenital surgical anomalies in the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Direct hyperbilirubinemia in newborns with gastroschisis.Pediatric surgery international · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brian C GulackDepartment of Surgery, Duke University Medical Center, Durham, NC; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC.
Matthew M LaughonDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Reese H ClarkPediatrix Medical Group, Inc, Sunrise, FL.
Terrance BurgessDuke Clinical Research Institute, Duke University Medical Center, Durham, NC.
Sybil RobinsonDuke Clinical Research Institute, Duke University Medical Center, Durham, NC.
Abdurrauf MuhammadDuke Clinical Research Institute, Duke University Medical Center, Durham, NC.
Angela ZhangDuke Clinical Research Institute, Duke University Medical Center, Durham, NC.
Adrienne DavisDuke Clinical Research Institute, Duke University Medical Center, Durham, NC.
Robert MortonDuke Clinical Research Institute, Duke University Medical Center, Durham, NC.
Vivian H ChuDepartment of Medicine, Duke University Medical Center, Durham, NC.
Christopher J ArnoldDepartment of Medicine, Duke University Medical Center, Durham, NC.
Christoph P HornikDuke Clinical Research Institute, Duke University Medical Center, Durham, NC; Department of Pediatrics, Duke University Medical Center, Durham, NC.
P Brian SmithDuke Clinical Research Institute, Duke University Medical Center, Durham, NC; Department of Pediatrics, Duke University Medical Center, Durham, NC. Electronic address: brian.smith@duke.edu.

Funding

Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
Increasing the Quality and Efficiency of Clinical Trials (R18)R18FD005292 · FDA · DUKE UNIVERSITY · PI LI, JENNIFER S · 2014 to 2019
$26.8M
Fungal biomarkers for diagnosis and response to therapy for pediatric candidemiaR01HD081044 · NICHD · DUKE UNIVERSITY · PI FISHER, BRIAN T, STEINBACH, WILLIAM J · 2014 to 2018
$3.2M
Cardiothoracic Surgical Network Clinical CenterU01HL088953 · NHLBI · DUKE UNIVERSITY · PI SMITH, PETER K · 2007 to 2013
$2.6M
Core Clinical Centers for the CTSNUM1HL088953 · NHLBI · DUKE UNIVERSITY · PI SMITH, PETER K · 2013 to 2017
$2.5M
NIH Summer Research Experience Programs (R25)R25HD076475 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2013 to 2023
$1.1M
Antimicrobial pharmacokinetics and outcomes in vulnerable infantsK23HD068497 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAUGHON, MATTHEW · 2011 to 2015
$586k
PATIENT SAFETY RESEARCH DURING NEONATAL CARE (R21)R21HD080606 · NICHD · DUKE UNIVERSITY · PI SMITH, PHILLIP BRIAN · 2015 to 2016
$457k
FDA HHS 1R18-FD005292-01FDA HHS R18 FD005292NCATS NIH HHS UL1 TR001117NCATS NIH HHS UL1TR001117NHLBI NIH HHS 5U01HL088953-05NHLBI NIH HHS U01 HL088953NHLBI NIH HHS UM1 HL088953NICHD NIH HHS 1R01-HD081044-01NICHD NIH HHS 1R25HD076475NICHD NIH HHS HHSN267200700051CNICHD NIH HHS HHSN275201000001GNICHD NIH HHS HHSN275201000001ZNICHD NIH HHS HHSN275201000003CNICHD NIH HHS HHSN275201000003INICHD NIH HHS K23 HD068497NICHD NIH HHS K23HD068497NICHD NIH HHS R01 HD081044NICHD NIH HHS R21 HD080606NICHD NIH HHS R25 HD076475NIDDK NIH HHS HHSN267200700051C
6 · The paper itself

Abstract

objectiveTo assess the effect of enteral feeding with human milk on the time from initiation of feeds to discharge after gastroschisis repair through review of a multi-institutional database. STUDY

designInfants who underwent gastroschisis repair between 1997 and 2012 with data recorded in the Pediatrix Medical Group Clinical Data Warehouse were categorized into 4 groups based on the percentage of days fed human milk out of the number of days fed enterally. Cox proportional hazards regression modeling was performed to determine the adjusted effect of human milk on the time from initiation of feeds to discharge.

resultsAmong 3082 infants, 659 (21%) were fed human milk on 0% of enteral feeding days, 766 (25%) were fed human milk on 1%-50% of enteral feeding days, 725 (24%) were fed human milk on 51%-99% of enteral feeding days, and 932 (30%) were fed human milk on 100% of enteral feeding days. Following adjustment, being fed human milk on 0% of enteral feeding days was associated with a significantly increased time to discharge compared with being fed human milk on 100% of enteral feeding days (hazard ratio [HR] for discharge per day, 0.46; 95% CI, 0.40-0.52). The same was found for infants fed human milk on 1%-50% of enteral feeding days (HR, 0.37; 95% CI, 0.32-0.41) and for infants fed human milk on 51%-99% of enteral feeding days (HR, 0.51; 95% CI, 0.46-0.57).

conclusionThe use of human milk for enteral feeding of infants following repair of gastroschisis significantly reduces the time to discharge from initiation of feeds.

Indexed as

Milk, HumanEnteral NutritionFemaleGastroschisisHumansInfant, NewbornIntensive Care Units, NeonatalIntubation, GastrointestinalLength of StayMalePatient DischargeProportional Hazards ModelsProspective StudiesTime Factors

Identifiers

PMID26703875
PMCPMC4769929

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.