ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
The Impact of Obesity and Diabetes on the Risk of Disease and Death due to Invasive Group A Streptococcus Infections in Adults.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 46 citations in OpenAlex.
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- Clinical characterization of anFrontiers in cellular and infection microbiology · 2026Article
- Risk and determinants of mortality associated with invasive group A streptococcus (iGAS) disease in Scotland: A national surveillance study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Article
- Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities.International journal of molecular sciences · 2025Review
- Managing toxic shock syndrome in immunosuppressed patient after liver transplantation from trauma to triumph: A case report.World journal of clinical cases · 2025Article
- Reprogramming aerobic metabolism mitigates Streptococcus pyogenes tissue damage in a mouse necrotizing skin infection model.Nature communications · 2025Article
- Descending necrotizing mediastinitis caused by Group AIDCases · 2025Article
- Association Between Diabetes Mellitus-Tuberculosis and the Generation of Drug Resistance.Microorganisms · 2024Review
- Is overweight a predictor for a more severe course of disease in cases of necrotizing fasciitis?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Invasive group A Streptococcus infection (Streptococcus pyogenes): Current situation in Spain.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024Article
- The intricate pathogenicity of Group AVirulence · 2024Review
- Frequency of Group APathogens (Basel, Switzerland) · 2024Article
- Toxic Shock Syndrome: Rare but Deadly.Cureus · 2024Article
- Structural Variances in Curcumin Degradants: Impact on Obesity in Mice.Journal of agricultural and food chemistry · 2024Article
- Gut microbiota changes associated with low-carbohydrate diet intervention for obesity.Open life sciences · 2024Article
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14 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundInvasive group A Streptococcus (iGAS) infections cause significant morbidity and mortality worldwide. We analyzed whether obesity and diabetes were associated with iGAS infections and worse outcomes among an adult US population.
methodsWe determined the incidence of iGAS infections using 2010-2012 cases in adults aged ≥ 18 years from Active Bacterial Core surveillance (ABCs), a population-based surveillance system, as the numerator. For the denominator, we used ABCs catchment area population estimates from the 2011 to 2012 Behavioral Risk Factor Surveillance System (BRFSS) survey. The relative risk (RR) of iGAS was determined by obesity and diabetes status after adjusting for age group, gender, race, and other underlying conditions through binomial logistic regression. Multivariable logistic regression was used to determine whether obesity or diabetes was associated with increased odds of death due to iGAS compared to normal weight and nondiabetic patients, respectively.
resultsBetween 2010 and 2012, 2927 iGAS cases were identified. Diabetes was associated with an increased risk of iGAS in all racial groups (adjusted risk ratio [aRR] ranged from 2.71 to 5.08). Grade 3 obesity (body mass index [BMI] ≥ 40) was associated with an increased risk of iGAS for whites (aRR = 3.47; 95% confidence interval [CI], 3.00-4.01). Grades 1-2 (BMI = 30.0-<40.0) and grade 3 obesity were associated with an increased odds of death (odds ratio [OR] = 1.55, [95% CI, 1.05, 2.29] and OR = 1.62 [95% CI, 1.01, 2.61], respectively) when compared to normal weight patients.
conclusionsThese results may help target vaccines against GAS that are currently under development. Efforts to develop enhanced treatment regimens for iGAS may improve prognoses for obese patients.
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