Evidence map›Paper›PMID 26703731›Full record

ArticleToxins2015

Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression.

Zhang Zhang, Yan Zhang, Minglei Shi, Bingyu Ye, Wenlong Shen, Ping Li, Lingyue Xing, Xiaopeng Zhang, Lihua Hou, Junjie Xu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 152 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Zhang ZhangBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. zzhnng@yeah.net.
Yan ZhangBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. zany1983@163.com.
Minglei ShiBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. shiml79@126.com.
Bingyu YeBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. byy0804@gmail.com.
Wenlong ShenBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. shenwl1988@gmail.com.
Ping LiBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. lipingtry@163.com.
Lingyue XingBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. xinglyinfo@163.com.
Xiaopeng ZhangBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. zxp8565@aliyun.com.
Lihua HouBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. houlihua@sina.com.
Junjie XuBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. xujunjie@sina.com.
Zhihu ZhaoBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. zhaozh@nic.bmi.ac.cn.
Wei ChenBeijing Institute of Biotechnology, No. 20, Dongdajie str., Fengtai District, Beijing 100071, China. cw0730@sina.com.
Beijing Fengtai Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. Previous studies found that ANTXR2 transcript abundance varies considerably in individuals of different ethnic/geographical groups, but no eQTLs (expression quantitative trait loci) have been identified. By using 3C (chromatin conformation capture), CRISPR-mediated genomic deletion and dual-luciferase reporter assay, gene loci containing cis-regulatory elements of ANTXR2 were localized. Two SNPs (single nucleotide polymorphism) at the conserved CREB-binding motif, rs13140055 and rs80314910 in the promoter region of the gene, modulating ANTXR2 promoter activity were identified. Combining these two regulatory SNPs with a previously reported SNP, rs12647691, for the first time, a statistically significant correlation between human genetic variations and anthrax toxin sensitivity was observed. These findings further our understanding of human variability in ANTXR2 expression and anthrax toxin susceptibility.

Indexed as

Antigens, BacterialBacterial ToxinsCell LineEnhancer Elements, GeneticGenetic Predisposition to DiseaseGenetic VariationHEK293 CellsHumansPolymorphism, Single NucleotidePromoter Regions, GeneticReceptors, Peptideanthrax toxinAntigens, BacterialANTXR2 protein, humanBacterial ToxinsReceptors, Peptideanthrax toxinANTXR2gene structuregenetic polymorphismgene transcription

Identifiers

PMID26703731
PMCPMC4728523
OpenAlexW2199982635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.