ArticleViruses2015
What Can We Learn from a Metagenomic Analysis of a Georgian Bacteriophage Cocktail?
Article in Viruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Complementary Activities of Bacteriophages and Antimicrobial Peptide Dendrimers Against Prosthetic Joint Infection Pathogens.Bioengineering (Basel, Switzerland) · 2026Article
- The effects of bacteriophage cocktail treatment on healthy gut microbiota: anMicrobial genomics · 2026Article
- A commercial bacteriophage cocktail failed to decolonize Zophobas morio larvae and promoted overgrowth of an OXA-48-producing Salmonella enterica.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Steering the course: targeting and exploiting surface receptors in phage therapy.Journal of bacteriology · 2026Review
- Bacteriophages and Endolysins Used in the Biocontrol ofMicroorganisms · 2025Review
- Characterization, Genomic Analysis and Application of Five Lytic Phages Against Carbapenem-ResistantMicroorganisms · 2025Article
- Phage diversity in One Health.Essays in biochemistry · 2024Review
- Sxt1, Isolated from a Therapeutic Phage Cocktail, Is a Broader Host Range Relative of the Phage T3.Viruses · 2024Article
- Variable fitness effects of bacteriophage resistance mutations inJournal of virology · 2024Article
- Article
- Guidelines to Compose an Ideal Bacteriophage Cocktail.Methods in molecular biology (Clifton, N.J.) · 2024Review
- A newFrontiers in microbiology · 2024Article
- Systematic analysis of putative phage-phage interactions on minimum-sized phage cocktails.Scientific reports · 2022Article
- The genetic basis of phage susceptibility, cross-resistance and host-range inMicrobiology (Reading, England) · 2021Article
- Phages from GenusViruses · 2021Article
- Comparative Analysis ofAntibiotics (Basel, Switzerland) · 2021Article
- Article
- Bacteriophage Therapy: Developments and Directions.Antibiotics (Basel, Switzerland) · 2020Review
- Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Phages for Phage Therapy: Isolation, Characterization, and Host Range Breadth.Pharmaceuticals (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phage therapy, a practice widespread in Eastern Europe, has untapped potential in the combat against antibiotic-resistant bacterial infections. However, technology transfer to Western medicine is proving challenging. Bioinformatics analysis could help to facilitate this endeavor. In the present study, the Intesti phage cocktail, a key commercial product of the Eliava Institute, Georgia, has been tested on a selection of bacterial strains, sequenced as a metagenomic sample, de novo assembled and analyzed by bioinformatics methods. Furthermore, eight bacterial host strains were infected with the cocktail and the resulting lysates sequenced and compared to the unamplified cocktail. The analysis identified 23 major phage clusters in different abundances in the cocktail, among those clusters related to the ICTV genera T4likevirus, T5likevirus, T7likevirus, Chilikevirus and Twortlikevirus, as well as a cluster that was quite distant to the database sequences and a novel Proteus phage cluster. Examination of the depth of coverage showed the clusters to have different abundances within the cocktail. The cocktail was found to be composed primarily of Myoviridae (35%) and Siphoviridae (32%), with Podoviridae being a minority (15%). No undesirable genes were found.
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