ArticleMarine drugs2015
Mycosporine-Like Amino Acids Promote Wound Healing through Focal Adhesion Kinase (FAK) and Mitogen-Activated Protein Kinases (MAP Kinases) Signaling Pathway in Keratinocytes.
Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Antioxidant and Anti-Aging Effects of Porphyra-334 Produced fromMarine drugs · 2026Article
- Unlocking the Potential of Red Seaweeds: A Special Focus onMarine drugs · 2025Review
- Article
- Applications of mycosporine-like amino acids beyond photoprotection.Applied and environmental microbiology · 2023Review
- Recent Advances and Future Prospects of Mycosporine-like Amino Acids.Molecules (Basel, Switzerland) · 2023Review
- Article
- Unraveling the Molecular Basis of Mycosporine Biosynthesis in Fungi.International journal of molecular sciences · 2023Article
- Identification of Volatiles of the DinoflagellateMarine drugs · 2022Article
- Cyanobacterial secondary metabolites towards improved commercial significance through multiomics approaches.World journal of microbiology & biotechnology · 2022Review
- Occurrence of Mycosporine-like Amino Acids (MAAs) from the Bloom-Forming CyanobacteriaMolecules (Basel, Switzerland) · 2022Article
- Genetic Engineering of Microalgae for Secondary Metabolite Production: Recent Developments, Challenges, and Future Prospects.Frontiers in bioengineering and biotechnology · 2022Review
- Microalgae as a Source of Mycosporine-like Amino Acids (MAAs); Advances and Future Prospects.International journal of environmental research and public health · 2021Review
- Acceleration of somatic cell reprogramming into the induced pluripotent stem cell using a mycosporine-like amino acid, Porphyra 334.Scientific reports · 2020Article
- The Potential of Cryptophyte Algae in Biomedical and Pharmaceutical Applications.Frontiers in pharmacology · 2020Review
- Absolute Configuration of Mycosporine-Like Amino Acids, Their Wound Healing Properties and In Vitro Anti-Aging Effects.Marine drugs · 2019Article
- Diverse Applications of Marine Macroalgae.Marine drugs · 2019Review
- UV Photoprotection, Cytotoxicity and Immunology Capacity of Red Algae Extracts.Molecules (Basel, Switzerland) · 2019Article
- Mycosporine-Like Amino Acids for Skin Photoprotection.Current medicinal chemistry · 2018Review
- Comprehensive Expression Profiling and Functional Network Analysis of Porphyra-334, One Mycosporine-Like Amino Acid (MAA), in Human Keratinocyte Exposed with UV-radiation.Marine drugs · 2017Article
- Quantitative analysis of mycosporine-like amino acids in marine algae by capillary electrophoresis with diode-array detection.Journal of pharmaceutical and biomedical analysis · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycosporine-like amino acids (MAAs) are secondary metabolites found in diverse marine, freshwater, and terrestrial organisms. Evidence suggests that MAAs have several beneficial effects on skin homeostasis such as protection against UV radiation and reactive oxygen species (ROS). In addition, MAAs are also involved in the modulation of skin fibroblasts proliferation. However, the regulatory function of MAAs on wound repair in human skin is not yet clearly elucidated. To investigate the roles of MAAs on the wound healing process in human keratinocytes, three MAAs, Shinorine (SH), Mycosporine-glycine (M-Gly), and Porphyra (P334) were purified from Chlamydomonas hedlyei and Porphyra yezoensis. We found that SH, M-Gly, and P334 have significant effects on the wound healing process in human keratinocytes and these effects were mediated by activation of focal adhesion kinases (FAK), extracellular signal-regulated kinases (ERK), and c-Jun N-terminal kinases (JNK). These results suggest that MAAs accelerate wound repair by activating the FAK-MAPK signaling pathways. This study also indicates that MAAs can act as a new wound healing agent and further suggests that MAAs might be a novel biomaterial for wound healing therapies.
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