ReviewMolecules (Basel, Switzerland)2015
Isocyanide-Based Multicomponent Reactions for the Synthesis of Heterocycles.
Review in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Multicomponent Reactions for the Synthesis of Oxazepines.Topics in current chemistry (Cham) · 2026Review
- Characterization of Novel Sigma Receptor Ligands Derived from Multicomponent Reactions as Efficacious Treatments for Neuropathic Pain.Pharmaceuticals (Basel, Switzerland) · 2026Article
- One-pot three-component synthesis of azaspirononatriene derivatives.Scientific reports · 2025Article
- Isocyanate-based multicomponent reactions.RSC advances · 2024Review
- Article
- Ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate in the smiles rearrangement reaction: straightforward synthesis of amino acid derived quinolin-2(1H)-one enamines.Molecular diversity · 2023Article
- Highly regioselective and diastereoselective synthesis of novel pyrazinoindolonesRSC advances · 2023Article
- Ugi Four-Component Reactions Using Alternative Reactants.Molecules (Basel, Switzerland) · 2023Review
- Multicomponent synthesis and photophysical study of novel α,β-unsaturated carbonyl depsipeptides and peptoids.Frontiers in chemistry · 2023Article
- Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media.International journal of molecular sciences · 2022Article
- Recent advances in the transition-metal-free synthesis of quinoxalines.RSC advances · 2021Review
- Electrochemical TEMPO-Catalyzed Oxidative Ugi-Type Reaction.ACS organic & inorganic Au · 2021Article
- Silica gel-immobilised chiral 1,2-benzenedisulfonimide: a Brønsted acid heterogeneous catalyst for enantioselective multicomponent Passerini reaction.RSC advances · 2021Article
- Three-Component Reactions of 3-Arylidene-3Molecules (Basel, Switzerland) · 2021Article
- Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.Journal of medicinal chemistry · 2020Article
- Two decades of recent advances of Ugi reactions: synthetic and pharmaceutical applications.RSC advances · 2020Review
- Nucleophilic Isocyanation.ACS omega · 2020Review
- Controlling the stereochemistry in 2-oxo-aldehyde-derived Ugi adducts through the cinchona alkaloid-promoted electrophilic fluorination.Beilstein journal of organic chemistry · 2020Article
- Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines.Molecules (Basel, Switzerland) · 2019Article
- Al(Salen) Metal Complexes in Stereoselective Catalysis.Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Multicomponent reactions (MCRs) are extremely popular owing to their facile execution, high atom-efficiency and the high diversity of products. MCRs can be used to access various heterocycles and highly functionalized scaffolds, and thus have been invaluable tools in total synthesis, drug discovery and bioconjugation. Traditional isocyanide-based MCRs utilize an external nucleophile attacking the reactive nitrilium ion, the key intermediate formed in the reaction of the imine and the isocyanide. However, when reactants with multiple nucleophilic groups (bisfunctional reactants) are used in the MCR, the nitrilium intermediate can be trapped by an intramolecular nucleophilic attack to form various heterocycles. The implications of nitrilium trapping along with widely applied conventional isocyanide-based MCRs in drug design are discussed in this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.