Trial reportJournal of cardiac failure2016
Hemodynamic Predictors of Heart Failure Morbidity and Mortality: Fluid or Flow?
Trial report in Journal of cardiac failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000619 (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness), which is not on this map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE)
Who cites it
66 citing papers in PubMed.
- Rates of Reversal of Volume Overload in Hospitalized Acute Heart Failure: Association With Long-term Kidney Function.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Trial
- Article
- Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes.JACC. Advances · 2026Article
- Assessing congestion in heart failure: tools are already available, but integration is key.Heart failure reviews · 2026Review
- Nocturia: when the heart wakes you up at night.World journal of urology · 2026Observational
- Cardiogenic Shock Systems of Care Best Practices. Part 1: Prehospital and Emergency Department Evaluation and Management.US cardiology · 2026Review
- Risk prediction in heart failure using invasive hemodynamics.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Emerging use of pulmonary artery and cardiac pressure sensing technology in the management of worsening heart failure events.Heart failure reviews · 2025Review
- Digital twins for noninvasively measuring predictive markers of right heart failure.NPJ digital medicine · 2025Article
- Renal Dysfunction Across the Spectrum of Cardiogenic Shock: Mechanisms, Clinical Implications, and Therapeutic Strategies.Current heart failure reports · 2025Review
- Artificial Intelligence ECG Diastolic Dysfunction and Survival in Cardiac Intensive Care Unit Patients.Journal of the American Heart Association · 2025Article
- Evaluation of the intraventricular hemodynamics of patients with left ventricular dysfunction via vector flow mapping.Frontiers in cardiovascular medicine · 2025Article
- Adequacy of Ambulatory Hemodynamic Assessments for Reducing All-Cause Mortality in Individuals With Heart Failure.International journal of heart failure · 2024Review
- Pulmonary artery elastance as a predictor of hospital mortality in heart failure cardiogenic shock.ESC heart failure · 2024Article
- Prognostic Significance of Hemodynamics in Patients With Transposition of the Great Arteries and Systemic Right Ventricle.Circulation. Heart failure · 2024Article
- Long-term outcomes of acute kidney injury in acute decompensated heart failure: identifying true cardiorenal syndrome and unveiling prognostic significance.Kidney research and clinical practice · 2024Article
- PREDICT HF: Risk stratification in advanced heart failure using novel hemodynamic parameters.Clinical cardiology · 2024Article
- Improved Prognostic Performance of Right Atrial Pressure-Corrected Cardiac Power Output in Pulmonary Hypertension and Heart Failure with Preserved Ejection Fraction.Journal of cardiovascular translational research · 2024Article
- Benchmarking Waitlist Mortality Prediction in Heart Transplantation Through Time-to-Event Modeling using New Longitudinal UNOS Dataset.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Contemporary approach to cardiogenic shock care: a state-of-the-art review.Frontiers in cardiovascular medicine · 2024Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Funding
Abstract
backgroundPatients with advanced heart failure may continue for prolonged times with persistent hemodynamic abnormalities; intermediate- and long-term outcomes of these patients are unknown. METHODS AND
resultsWe used ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) trial data to examine characteristics and outcomes of patients with invasive hemodynamic monitoring during an acute heart failure hospitalization. Patients were stratified by final measurement of cardiac index (CI; L/min/m2) and pulmonary capillary wedge pressure (PCWP; mmHg) before catheter removal. The study groups were CI ≥ 2/PCWP < 20 (n = 74), CI ≥ 2/PCWP ≥ 20 (n = 37), CI < 2/PCWP < 20 (n = 23), and CI < 2/PCWP ≥ 20 (n = 17). Final CI was not associated with the combined risk of death, cardiovascular hospitalization, and transplantation (hazard ratio [HR]1.03, 95% confidence interval 0.96-1.11 per 0.2 L/min/m2 decrease, P = .39), but final PCWP ≥ 20 mmHg was associated with increased risk of these events (HR 2.03, 95% confidence interval 1.31-3.15, P < .01), as was higher final right atrial pressure (HR 1.09, 95% confidence interval 1.06-1.12 per mmHg increase, P < .01).
conclusionFinal PCWP and final right atrial pressure were stronger predictors of postdischarge outcomes than CI in patients with advanced heart failure. The ability to lower filling pressures appears to be more prognostically important than improving CI in the management of patients with advanced heart failure. ClinicalTrials.govIdentifier: NCT00000619.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.