ArticleCritical care (London, England)2015
Judging quality of current septic shock definitions and criteria.
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis.British journal of anaesthesia · 2019Pooled it
- Pooled it
- LINC00963 targeting miR-98-5p exacerbates sepsis-induced myocardial injury.Internal and emergency medicine · 2026Article
- Associations between Organ Dysfunction Scoring Systems and Dysregulated Host Responses in Adults with Severe Infection in Uganda: A Prospective Cohort Study.The American journal of tropical medicine and hygiene · 2025Article
- Validation of MEWS, NEWS, NEWS-2 and qSOFA for different infection foci at the emergency department, the acutelines cohort.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Exosomes as novel biomarkers in sepsis and sepsis related organ failure.Journal of translational medicine · 2024Review
- Adjunctive immunotherapeutic agents in patients with sepsis and septic shock: a multidisciplinary consensus of 23.Journal of anesthesia, analgesia and critical care · 2024Article
- FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression.Frontiers in pharmacology · 2024Article
- Paediatrics: how to manage septic shock.Drugs in context · 2021Review
- miR-21-5p inhibits inflammation injuries in LPS-treated H9c2 cells by regulating PDCD4.American journal of translational research · 2021Article
- Application of The Sepsis-3 Consensus Criteria in a Geriatric Acute Care Unit: A Prospective Study.Journal of clinical medicine · 2019Article
- Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity.Critical care (London, England) · 2018Article
- Maternal sepsis.Seminars in perinatology · 2018Review
- New definitions for septic shock-a roadmap for a better clinical outcome?Journal of thoracic disease · 2016Article
- Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes.Critical care (London, England) · 2016Article
- Much Ado About the New Definitions of Sepsis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Septic shock definitions are being revisited. We assess the feasibility, reliability, and validity characteristics of the current definitions and criteria of septic shock. Septic shock is conceptualised as cardiovascular dysfunction, tissue perfusion and cellular abnormalities caused by infection. Currently, for feasibility, septic shock is identified at the bedside by using either hypotension or a proxy for tissue perfusion/cellular abnormalities (e.g., hyperlactatemia). We propose that concurrent presence of cardiovascular dysfunction and perfusion/cellular abnormalities could improve validity of septic shock diagnosis, as we are more likely to identify a patient population with all elements of the illness concept. This epidemiological refinement should not affect clinical care and may aid study design to identify illness-specific biomarkers and interventions.
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