ArticleFertility and sterility2016
Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 expression and regulation in uterine leiomyoma.
Article in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Epigenomic and enhancer dysregulation in uterine leiomyomas.Human reproduction update · 2022Review
- Establishing a reproductive biorepository for basic and translational research: experience developing the reproductive subjects registry and sample repository.Journal of assisted reproduction and genetics · 2021Article
- High-throughput sequencing study of the effect of transabdominal hysterectomy on intestinal flora in patients with uterine fibroids.BMC microbiology · 2020Article
- Uterine fibroid management: from the present to the future.Human reproduction update · 2016Review
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
objectiveTo determine the presence, differential expression, and regulation of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) in uterine leiomyomas.
designLaboratory in vivo and in vitro study with the use of human leiomyoma and myometrial tissue and primary cells.
settingAcademic medical center. SAMPLE(S): Leiomyoma and myometrial tissue samples and cultured cells. INTERVENTION(S): 5-Aza-2'-deoxycytidine (5-aza-dC) treatment. MAIN OUTCOME MEASURE(S): Fold-change difference between EFEMP1 and fibulin-3 expression in leiomyoma tissue and cells compared with matched myometrial samples, and fold-change difference in EFEMP1 expression with 5-Aza-dC treatment. RESULT(S): In vivo, EFEMP1 expression was 3.19-fold higher in myometrial tissue than in leiomyoma tissue. EFEMP1 expression in vitro was 5.03-fold higher in myometrial cells than in leiomyoma cells. Western blot and immunohistochemistry staining of tissue and cells confirmed similar findings in protein expression. Treatment of leiomyoma cells with 5-Aza-dC resulted in increased expression of EFEMP1 in vitro. CONCLUSION(S): The EFEMP1 gene and its protein product, fibulin-3, are both significantly down-regulated in leiomyoma compared with myometrium when studied both in vivo and in vitro. The increase in EFEMP1 expression in leiomyoma cells with 5-Aza-dC treatment suggest that differential methylation is responsible, in part, for the differences seen in gene expression.
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