ArticleScience advances2015
Structural-functional connectivity deficits of neocortical circuits in the Fmr1 (-/y) mouse model of autism.
Article in Science advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- A systematic review of the relationship between magnetic resonance imaging based resting-state and structural networks in the rodent brain.Frontiers in neuroscience · 2023Pooled it
- Autism subtypes identified using cross-species functional connectivity analyses.Nature neuroscience · 2026Article
- A common computational and neural anomaly across mouse models of autism.Nature neuroscience · 2025Article
- Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging.Bone research · 2025Article
- Biological subtyping of autism via cross-species fMRI.bioRxiv : the preprint server for biology · 2025Article
- Delayed onset of striatal projection neuron hyperexcitability inFrontiers in cellular neuroscience · 2025Article
- Mechanisms of brain overgrowth in autism spectrum disorder with macrocephaly.Frontiers in neuroscience · 2025Review
- Peripheral contributions to resting state brain dynamics.Nature communications · 2024Article
- Local and long-range input balance: A framework for investigating frontal cognitive circuit maturation in health and disease.Science advances · 2024Review
- Article
- CDKL5 sculpts functional callosal connectivity to promote cognitive flexibility.Molecular psychiatry · 2024Article
- Topography and Ensemble Activity in the Auditory Cortex of a Mouse Model of Fragile X Syndrome.eNeuro · 2024Article
- Developmental Disruptions of the Dorsal Striatum in Autism Spectrum Disorder.Biological psychiatry · 2024Review
- Mapping and comparing fMRI connectivity networks across species.Communications biology · 2023Review
- Endogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1Nature communications · 2023Article
- Article
- Sleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics.Neurobiology of sleep and circadian rhythms · 2023Review
- Investigating cell-specific effects of FMRP deficiency on spiny projection neurons in a mouse model of Fragile X syndrome.Frontiers in cellular neuroscience · 2023Article
- Abnormal Whisker-Dependent Behaviors and Altered Cortico-Hippocampal Connectivity in Shank3b-/- Mice.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fragile X syndrome (FXS), the most common inherited form of intellectual disability disorder and a frequent cause of autism spectrum disorder (ASD), is characterized by a high prevalence of sensory symptoms. Perturbations in the anatomical connectivity of neocortical circuits resulting in their functional defects have been hypothesized to contribute to the underlying etiology of these disorders. We tested this idea by probing alterations in the functional and structural connectivity of both local and long-ranging neocortical circuits in the Fmr1 (-/y) mouse model of FXS. To achieve this, we combined in vivo ultrahigh-field diffusion tensor magnetic resonance imaging (MRI), functional MRI, and viral tracing approaches in adult mice. Our results show an anatomical hyperconnectivity phenotype for the primary visual cortex (V1), but a disproportional low connectivity of V1 with other neocortical regions. These structural data are supported by defects in the structural integrity of the subcortical white matter in the anterior and posterior forebrain. These anatomical alterations might contribute to the observed functional decoupling across neocortical regions. We therefore identify FXS as a "connectopathy," providing a translational model for understanding sensory processing defects and functional decoupling of neocortical areas in FXS and ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.